Effect of Intake of Dehydrated Nopal Powder From Highly Mature Cladodes on the Lipid Profile

Universidad Autónoma de Querétaro35 enrolled

Overview

Background: Opuntia ficus-indica is a plant from the cactus family (Cactaceae) that is widespread and of great economic importance in Mexico. It has been consumed as food since pre-Hispanic times and is currently considered a nutraceutical. In this study, the effect of consumption of dehydrated nopal powder from highly mature cladodes (Opuntia ficus-indica) on the lipid profile of overweight or obese patients diagnosed with dyslipidemia was investigated. Methods: A 3-month prospective clinical trial was conducted in 35 overweight or obese patients with dyslipidemia. The sample was divided into three groups with a daily intake of 30 g of dietary fiber: Group I received 5 g of dehydrated Opuntia ficus-indica cladodes plus the standard normocaloric diet for dyslipidemia, Group II received 15 g plus the diet, and Group III followed only the diet.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Overweight Obesity Dyslipidemia

Interventions

supplementation with 5 g dehydrated nopal powder from highly mature cladodesDIETARY_SUPPLEMENT

Group I received 5 g of dehydrated Opuntia ficus-indica cladodes plus the standard normocaloric diet for dyslipidemia.

supplementation with 15 g dehydrated nopal powder from highly mature cladodesDIETARY_SUPPLEMENT

Group II received 15 g plus the diet, and Group III followed only the diet.

Control Group (only diet)OTHER

No dehydrated nopal or placebo. Diet: 30 g of fiber per day Normocaloric diet Carbohydrates 55%, Lipids 25% and Proteins 20%

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Participants with dyslipidemia, confirmed by lipid meas-urement in blood chemistry * overweight or obesity * A cardiovascular risk factor associated with abdominal obesity Exclusion Criteria: * Patients with a suspected diagnosis of primary dyslipidemia * Diabetes * Hypertension * Thyroid disease were excluded from the study * Patients with complex or severe disease such as heart failure, liver or kidney disease * Pregnant or lactating women * Indidividuals taking lipid-modifying drugs or hormone replacement therapy - Patients with gastrointestinal problems and deficiencies

Outcomes

Primary Outcomes

Blood lipid levels

A blood sample (3 ml) was taken from the patients after fasting for 12 hours, then prepared for subsequent analysis by an enzymatic method. The Clinical 50 VWR cen-trifuge ® was used for sample preparation and the Roche Cobas C 111 ® kit for lipid analysis of the samples. These analyses were performed in duplicate. Comparison of supplementation with dehydrated nopal powder from highly mature cladodes, by group, in initial and final values of the lipid profile: Total cholesterol; LDL, Low-density lipoproteins; HDL, High-density lipoproteins; TGL, Tri-glycerides.

Time frame: From enrollment to the end of treatment at 12 weeks