This study will examine whether the use of synthetic carbon apatite bone graft material will lead to more bone formation compared to human derived allograft and bovine derived xenograft material.
Bone grafts are commonly placed to increase the amount of bone right after tooth extraction and prepare the site for future dental implant placement. 45 patients requiring a tooth extraction will be recruited and randomized to receive either allograft, xenograft, or synthetic bone grafting.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
45
After tooth extraction, the socket will be filled with a collagen plug and bone graft.
University of Michigan School of Dentistry
Ann Arbor, Michigan, United States
Clinical alveolar ridge dimension changes
Clinically measured alveolar ridge dimension changes in mm
Time frame: 4 months
Histological bone density
Histomorphometry
Time frame: 4 months
Presence of bone turnover proteins
Immunohistochemistry
Time frame: 4 months
Alveolar volumetric changes following tooth extraction
Digitally measured alveolar ridge changes in mm\^3 using CBCT
Time frame: 4 months
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