The goal of this open label study is to measure pharmacokinetics, pharmacodynamics, early efficacy, and safety of tanruprubart in adult and pediatric participants, in the United States, Canada, and Europe.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Solution for IV infusion.
HonorHealth Bob Bové Neuroscience Institute
Scottsdale, Arizona, United States
RECRUITINGChildren's Hospital of Orange County
Orange, California, United States
RECRUITINGArea Under the Tanruprubart Serum Concentration-time Curve to the Last Sample (AUC0-t)
Time frame: Up to Day 15
Observed Time to Maximum Observed Serum Concentration (Cmax) (Tmax) of Tanruprubart
Time frame: Up to Day 15
Change From Baseline in Free Component of Complement Complex (C1q) Protein Concentration in Serum
Time frame: Baseline up to Day 15
Change from Baseline in Medical Research Council (MRC) Sumscore at Week 1
Time frame: Baseline, Week 1
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University of California Irvine
Orange, California, United States
University of Colorado Hospital
Aurora, Colorado, United States
RECRUITINGOchsner LSU Health
Shreveport, Louisiana, United States
RECRUITINGUniversity Massachusetts Chan Medical School
Worcester, Massachusetts, United States
RECRUITINGHenry Ford Health
Detroit, Michigan, United States
RECRUITINGMayo Rochester
Rochester, Minnesota, United States
RECRUITINGAarhus University Hospital
Aarhus, Aarhus N, Denmark
RECRUITING