The goal of this open label study is to measure pharmacokinetics, pharmacodynamics, early efficacy, and safety of tanruprubart in adult and pediatric participants, in the United States, Canada, and Europe.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Solution for IV infusion.
Children's Hospital of Orange County
Orange, California, United States
RECRUITINGUniversity of California Irvine
Orange, California, United States
RECRUITINGHenry Ford Health
Detroit, Michigan, United States
RECRUITINGArea Under the Tanruprubart Serum Concentration-time Curve to the Last Sample (AUC0-t)
Time frame: Up to Day 15
Observed Time to Maximum Observed Serum Concentration (Cmax) (Tmax) of Tanruprubart
Time frame: Up to Day 15
Change From Baseline in Free Component of Complement Complex (C1q) Protein Concentration in Serum
Time frame: Baseline up to Day 15
Change from Baseline in Medical Research Council (MRC) Sumscore at Week 1
Time frame: Baseline, Week 1
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Mayo Rochester
Rochester, Minnesota, United States
RECRUITING