A Study to Evaluate the Safety, Tolerability and PK of SK-08

Inclusion Criteria: 1. Healthy male and female participants aged 18 to 45 years (inclusive). 2. Male participants: Body weight ≥50 kg; Female participants: Body weight ≥45 kg; Body mass index (BMI) between 19.0 and 26 kg/m². 3. Participants must have no plans for conception during the trial and for 3 months after the last dose, and must voluntarily use effective contraception with no plans for sperm or egg donation . 4. Capable of understanding and voluntarily providing written informed consent prior to any study-related procedures. Exclusion Criteria: 1. Have a specific history of allergies or have an allergic constitution； 2. Have a history of chronic diseases or severe diseases in the cardiovascular, liver, kidney, biliary tract, respiratory, blood and lymphatic, endocrine, immune, mental, neuromuscular, gastrointestinal systems, etc. 3. Developed acute diseases from 2 weeks before screening to before randomization ; 4. Patients with previous or current hypotension or insufficient blood volume, intracranial hypertension or cerebral hemorrhage, or those with ocular diseases (such as angle-closure glaucoma), who are not suitable for inclusion after assessment by the researcher; 5. Those with clinical significance hypokalemia, hyperkalemia, hypomagnesemia, hypermagnesemia, hypocalcemia, and hypercalcemia; 6. Those who have used any drugs or health supplements from 2 weeks before screening to randomization ; 7. Any drugs that may interact with this product have been used from 30 days before screening to randomization, such as CYP450 inhibitors or inducers ; 8. Those who have undergone major surgical operations from 6 months before screening , or who plan to undergo surgery during the study period, or who have undergone surgeries as judged by the investigator to affect drug absorption, distribution, metabolism, and excretion; 9. Those who have received live attenuated vaccine inoculation from 2 weeks before screening to randomization or those who need to receive live attenuated vaccine inoculation during the trial; 10. Those who had a history of alcohol abuse within one year before screening； 11. Those who smoked more than 5 cigarettes per day on average within 3 months before screening and before randomization, or were unable to stop using any tobacco products during the trial period; 12. Those who cannot tolerate venipuncture/indwelling needles or have a history of fainting from needles or blood ; 13. Other researchers determined that the subjects were not suitable to participate.