Sepsis and Hospital Mortality

N/ARecruitingNCT07022041

University of Calabria100 enrolled

Overview

Sepsis is one of the leading causes of hospital mortality, with a rate of approximately 20% (World Health Organization) among vulnerable patients admitted to high-intensity care units such as CCUs and inpatient wards. Currently, diagnostic criteria such as the Systemic Inflammatory Response Syndrome (SIRS) and the Sequential Organ Failure Assessment (SOFA) score, although widely used, lack sufficient specificity and accuracy. No established parameters are available for early and timely diagnosis. This study aims to address this gap by investigating the variability of blood plasma conductivity and dielectric constant using microwave probes previously validated for non-invasive glucose monitoring. The acquired data will be analyzed using the Anritsu VectorStar VNA to identify innovative and reliable parameters associated with the presence of severe infections.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Sepsis

Interventions

conductivity and dieletric constantDIAGNOSTIC_TEST

collecting blood samples and directly measuring plasma conductivity and dielectric constant using microwave probes already validated for non-invasive glucose monitoring.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years * Cardiology patients without documented infection (Control Group) * Patients with sepsis * Patients with nosocomial infection * Patients with myocarditis, endocarditis, or pericarditis * Ability to provide written informed consent Exclusion Criteria: * Patients with severe or chronic medical conditions that may interfere with study results, such as autoimmune diseases, renal or hepatic failure * Patients taking medications that could affect the measured biophysical parameters, such as corticosteroids or immunosuppressants * Patients with cancer * Patients with diseases involving the immune system (e.g., lymphomas, leukemias) * Patients with congenital or acquired immunodeficiencies (e.g., HIV) * Patients who are unable to read and sign the informed consent form

Outcomes

Primary Outcomes

Comparative Analysis of Plasma Bioelectrical Properties in Sepsis

differences in blood plasma conductivity and dielectric constant will be analyzed between patients with and without sepsis, using validated microwave probes and appropriate statistical methods.

Time frame: through study completion, an average of 10 days

Secondary Outcomes

Correlation Between Biophysical Parameters and Conventional Infection and Inflammation Biomarkers

correlations will be assessed between measured biophysical parameters and conventional infection/inflammation biomarkers (e.g., ESR, procalcitonin, CRP, and white blood cell count) in patients with suspected or confirmed infection.

Time frame: through study completion, an average of 3 months