⁶⁸Ga-DPA in the Lung Cancer Diagnosis

Early Phase 1Enrolling By InvitationNCT07023068

Peking Union Medical College Hospital40 enrolled

Overview

In previous studies, we synthesized a PD-L1-targeted molecular probe, ⁶⁸Ga-DPA, and developed a ⁶⁸Ga-DPA injection for clinical research. Preliminary studies demonstrated its favorable safety profile and excellent imaging performance. Leveraging the established strengths of the Department of Nuclear Medicine at Peking Union Medical College Hospital, we now plan to conduct an exploratory PET/CT imaging study in lung cancer patients. This study aims to provide an in vivo, non-invasive, and visualizable technique for detecting PD-L1 expression levels and spatial distribution in tumors. It will further validate the clinical utility of this technology, offering critical diagnostic insights for initial assessment and treatment efficacy evaluation in PD-L1-positive tumor patients undergoing PD-L1-targeted therapies.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Lung Cancers

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years, regardless of gender. * Patients clinically confirmed or suspected of lung cancer, with pathological specimens obtainable via biopsy or surgery within the recent 2 months. * At least one measurable target lesion according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. * Expected survival \>3 months. Exclusion Criteria: * Severe hepatic or renal dysfunction (serum creatinine \>3.0 mg/dL or any liver enzyme level ≥5× upper limit of normal). * Women who are planning pregnancy, pregnant, or breastfeeding. * Inability to lie supine for 30 minutes. * Claustrophobia or other psychiatric disorders. * Intolerance to any clinical procedures in the study. * Other conditions deemed ineligible by the investigator.

⁶⁸Ga-DPA in the Lung Cancer Diagnosis

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes