NLR and PLR Levels Following PENG Block in Hip Arthroplasty

Poznan University of Medical Sciences60 enrolled

Overview

Effect of PENG block on NLR and PLR following hip arthroplasty

The NLR is a sensitive indicator of inflammation confirmed in numerous studies and has a predictive and prognostic value. NLR is a cheap, simple, fast-acting, readily available stress and inflammation parameter with high sensitivity and low specificity. Dynamic changes in the NLR precede the clinical state by several hours and may alert clinicians to the ongoing pathological process early. NLR is a new promising marker of cellular immune activation, an important indicator of stress and systemic inflammation. It opens a new dimension for clinical medicine, enabling a better understanding of the biology of inflammation, the linkage and antagonism between innate and adaptive immunity, and their clinical consequences for health and disease. NLR is affected not only by surgical trauma but also by the method of anesthesia. In recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized. However, there have been very few studies evaluating the effect of various methods of anesthesia on the NLR.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Hip Arthropathy Hip Osteoarthritis Hip Pain Chronic

Interventions

0.9% Sodium Chloride InjectionDRUG

After spinal anesthesia, the ultrasound-guided PENG block will be performed with 20ml of 0.9% sodium chloride

Ropivacaine 0.2% Injectable SolutionDRUG

After spinal anesthesia, the ultrasound-guided PENG block will be performed with 20 ml of 0.2% ropivacaine

Eligibility

Sex: ALLMin age: 60 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with ASA classification I-III * Aged 60-100 years * Who will be scheduled for hip arthroplasty under spinal anesthesia Exclusion Criteria: * Patients who have a history of bleeding diathesis * Take anticoagulant therapy * History of chronic pain before surgery * Multiple trauma * patients unable to assess their pain (dementia) * patients operated under general anesthesia * patients having an infection in the region of the procedure * the patient who does not accept the procedure

Locations (1)

Poznan University of Medical Sciences

Poznan, Poland

Outcomes

Primary Outcomes

Neutrophil-to-lymphocyte ratio

Neutrophil to lymphocyte ratio (NLR) is used as a marker of subclinical inflammation. It is calculated by dividing the number of neutrophils by number of lymphocytes, usually from peripheral blood sample, but sometimes also from cells that infiltrate tissue, such as tumor.

Time frame: 12 hours after surgery

Secondary Outcomes

PLR

Platelet-to-lymphocyte ratio

Time frame: 12 hours after surgery

PLR

Platelet-to-lymphocyte ratio

Time frame: 24 hours after surgery

PLR

Platelet-to-lymphocyte ratio

Time frame: 48 hours after surgery

NLR

Neutrophil-to-lymphocyte ratio

Time frame: 24 hours after surgery

NLR

Neutrophil-to-lymphocyte ratio

Time frame: 48 hours after surgery

first need of opiate

Time after surgery when the patient needs opiate for the first time

Time frame: 48 hours after procedure

Opioid Consumption

Total opiate consumption after surgery

Time frame: 48 hours after surgery

Pain score

NRS (Numerical Rating Scale) - ranging from 0 to 10, where 0 represents "no pain" and 10 represents the "worst pain imaginable"

Data from ClinicalTrials.gov

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