MLPR As A Diagnostic Marker For Acute Pulmonary Embolism

Ain Shams University53 enrolled

Overview

A retrospective study to assess the utility of hematological marker (monocyte to large platelet ratio) to diagnose patients with pulmonary embolism

The investigators conducted a retrospective review of emergency department records of patients who presented with signs and symptoms suggestive of pulmonary embolism (PE) and underwent CT pulmonary angiography (CTPA) for diagnosis. Hematological laboratory findings obtained prior to any treatment were collected and compared between two groups based on CTPA results: those with confirmed PE (CT positive) and those without PE (CT negative).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pulmonary Embolism (Diagnosis)Diagnosis

Interventions

Monocyte to Large Platelet Ratio (MLPR)DIAGNOSTIC_TEST

Admission laboratory values were used to calculate the Monocyte-to-Large Platelet Ratio (MLPR) by dividing the absolute monocyte count by the large platelet count. These values were obtained from blood samples collected before any treatment was administered.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Only patients with the results of full blood count and white blood cell differentiation, measured before the treatment of suspected PE. * Patients underwent CT pulmonary angiography to confirm or exclude pulmonary embolism diagnosis. Exclusion Criteria: * Patient with history of any myeloproliferative disorder, myelofibrosis, Glanzmann thrombasthenia, May-Hegglin anomaly, Bernard-Soulier syndrome, suspicion of disseminated intravascular coagulation. * Patient receiving any anticoagulant drug at a therapeutic dose. * Patient with blood transfusion in the last 2 months. * Patients with acute coronary syndrome, pulmonary edema. * Patient on immunosuppressive drugs , Oral contraceptive pills . * Patients with severe renal or hepatic disease. * Patients with Stroke. * Patients with malignancy.

Locations (1)

Ain Shams University

Cairo, Egypt

Outcomes

Primary Outcomes

Monocyte-to-Large Platelet Ratio (MLPR)

A ratio between monocyte absolute count and the large platelets count (MLPR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by area under the curve (AUC) , sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).