Does Intralipid Infusion Can Reverse the Spinal Anesthesia Effect in Day Case Surgery?

Benha University200 enrolled

Overview

This study aims to evaluate the effect of intralipid infusion on reversing the spinal anesthesia effect in day case surgery.

The increasing demand for day-case surgery has led to a growing interest in developing strategies to provide patients with a more convenient, cost-effective, and less invasive alternative to traditional inpatient procedures. Spinal anesthesia, in particular, is a widely used technique in day-case surgery due to its ability to provide excellent analgesia with minimal side effects. Intravenous lipid emulsion therapy is commonly used to treat local anesthetic systemic toxicity (LAST) and has demonstrated some efficacy in treating other drug toxicities, particularly cardiotoxicity from lipophilic drugs.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

200

Conditions

Intralipid Infusion Spinal Anesthesia Day Case Surgery

Interventions

Lipid emulsionOTHER

Patients (\>70kg will receive 100 ml, \<70 will receive 1.5ml/kg) of 20% intravenous lipid emulsion at the end of surgery as a study group.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age from 18 to 65 years. * Both sexes. * American Society of Anesthesiology (ASA) physical status I-II. * Scheduled for day-case surgery under spinal anesthesia. * Time of surgery less than 90 min. Exclusion Criteria: * Patients with contraindications for outpatient surgery or spinal anesthesia. * Local anaesthetic (LA) allergy. * Those receiving anticoagulant therapy. * Emergency cases. * Pregnant cases.

Locations (1)

Banha University

Banhā, Banha, Egypt

Outcomes

Primary Outcomes

Onset time of the motor block

The onset time of the motor block using the modified Bromage scale will be assessed. The motor block will be measured when the maximum dermatomal spread is achieved using the modified Bromage scale (0: no motor block, 1: hip blocked, 2: hip and knee blocked, and 3: hip, knee, and ankle blocked).

Time frame: Intraoperatively

Secondary Outcomes

Duration of motor block

The motor block will be measured when the maximum dermatomal spread is achieved using the modified Bromage scale (0: no motor block, 1: hip blocked, 2: hip and knee blocked, and 3: hip, knee, and ankle blocked).

Time frame: Intraoperatively

Time till home readiness

The time to home readiness will be assessed as the time from the end of surgery until the patients reached a post-anesthesia discharge score (PADS) ≥9 and are able to void spontaneously.

Time frame: 24 hours postoperatively

Time to the 1st rescue analgesia

Time to the first request for the rescue analgesia (time from end of surgery to first dose of tramadol administrated).

Time frame: 24 hours postoperatively

Total tramadol consumption

Rescue analgesia of 100mg IV tramadol will be given if the numerical rating scale (NRS)\> 3 to be repeated after 30 min if pain persists (with maximum dose 400mg) until the NRS \< 4.

Time frame: 24 hours postoperatively

Degree of pain

Each patient will be instructed about postoperative pain assessment with the numerical rating scale (NRS). NRS (0 represents "no pain" while 10 represents "the worst pain imaginable").

Time frame: 24 hours postoperatively

Data from ClinicalTrials.gov

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