Noninvasive Intratumor Heterogeneity Evaluation in HNSCC

First Affiliated Hospital of Chongqing Medical University700 enrolled

Overview

This study focuses on tumor heterogeneity, a core challenge in the field of oncology, and innovatively utilizes patient imaging data to deeply mine and analyze intratumoral heterogeneity. By constructing an imaging analysis model for tumor heterogeneity and associating this model with clinical, pathological, transcriptomic, and metabolomic data of patients, a multi-omics decoding of tumor heterogeneity is achieved. The main questions it aims to address are: Can the ITH model stratify patients' treatment efficacy and prognosis assessment? Can pathological and multi-omics sequencing map the mechanisms behind the ITH model?

Study Type

OBSERVATIONAL

Enrollment

700

Conditions

Head and Neck Cancer

Eligibility

Sex: ALLMin age: 15 YearsMax age: 89 Years

Medical Language ↔ Plain English

Inclusion Criteria: Pathologically confirmed head and neck squamous cell carcinoma (HNSCC). Complete clinical, imaging, and pathological data. Available complete follow-up information. Exclusion Criteria: Patients who received chemotherapy or radiotherapy before surgery. Poor image quality. Tumors too small to be easily identified. History of other concurrent malignant tumors.

Locations (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China

Outcomes

Primary Outcomes

AUC

Time frame: through study completion, an average of 1 year

C-index