VAM in Secondary AML, AML With Extramedullary Involvement, and Myeloid Sarcoma

Inclusion Criteria: 1. The patient fully understands this study, voluntarily participates, and signs the informed consent form (ICF) 2. Age 18-65 years 3. Clinically diagnosed, previously untreated acute myeloid leukemia (non-APL), meeting any one of the following criteria: a. Secondary acute myeloid leukemia; b. Therapy-related acute myeloid leukemia; c. AML with extramedullary/myeloid sarcoma; d. Age ≥60 years, assessed as fit-AML; 4. Normal cardiac function, with left ventricular ejection fraction (LVEF) ≥50% 5. Liver and kidney function: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5 times the upper limit of normal (ULN) (≤5 times ULN for patients with liver involvement); total bilirubin ≤1.5 times ULN; serum creatinine ≤1.5 times ULN 6. Eastern Cooperative Oncology Group (ECOG) performance status score: 0-2 Exclusion Criteria: 1. Assessed as unfit- or frail-AML; 2. Patients with a history or concurrent diagnosis of other malignancies requiring treatment 3. Uncontrolled systemic diseases (e.g., advanced active infections, uncontrolled hypertension, etc.) 4. Known history of immediate or delayed hypersensitivity reactions to the same class of study drugs or excipients 5. Pregnant or breastfeeding women, or patients who refuse to use effective contraception during the study period 6. Patients with a history of severe neurological or psychiatric disorders 7. Other severe medical conditions, such as myocardial infarction, severe or unstable angina, severe arrhythmias 8. Cerebrovascular events (including transient ischemic attacks), etc. 9. Known infection with human immunodeficiency virus (HIV); active hepatitis B or C infection; inactive hepatitis carriers or subjects with low viral titers after receiving non-prohibited antiviral therapy are not excluded 10. Subjects who have received strong or moderate CYP3A inducers/inhibitors or strong P-gp inhibitors or related foods within 7 days before starting the study treatment 11. Patients unable to take oral medications or with malabsorption syndrome 12. Patients deemed by the investigator to be unsuitable for participation in the study