Assessment of Er:YAG Laser-Assisted Surgical Treatment in Medication-Related Osteonecrosis of the Jaw (MRONJ): A Clinical Trial

Wroclaw Medical University65 enrolled

Overview

The aim of this study is assessing the effectiveness of the Er:YAG laser in relation to the use of conventional surgery in the treatment of drug-induced osteonecrosis of the jaws (MRONJ). The study compares two main treatments for advanced cases of MRONJ or cases that do not show improvement despite conservative or non-surgical treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Medication-Related Osteonecrosis of Jaw

Interventions

irradiation with Er:YAG laserPROCEDURE

An Er:YAG laser (LightTouch, LightInstruments, Yokneam, Israel) was used with the following parameters: 400mJ (millijoules), 6W (Watt), 15Hz (Hertz), 5/8 water cooling, laser tip with a diameter of 800 microns. Tissue debridement continued until hard, healthy, lively bleeding bone was exposed, indicative of normal bone.

Tissue preparationPROCEDURE

Rose-shaped rotary drills (8 mm diameter) were used with water cooling at a speed not exceeding 40.000 rpm. Tissue preparation limits were consistent with those used for the Er:YAG laser group.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * confirmed diagnosis of MRONJ Exclusion Criteria: * head and neck radiotherapy * cases requiring hospital admission due to poor general condition

Locations (1)

Wroclaw Medical University

Wroclaw, Poland

Outcomes

Primary Outcomes

Complications

Occurrence or absence of complications

Time frame: Up to 6 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.