In order to reduce the clinical demand for kidney dialysis rate of Diabetic Kidney Disease(DKD) patients, a bidirectional cohort study of 4472 patients with DKD (Qi deficiency and collateral stasis syndrome) was carried out based on a preliminary DKD cohort of 13,000 patients. The exposure factor was supplementing and reducing the kidney turbidity-Huoxue Tongluo method represented by the addition and subversion of Shenzhuo prescription, and the incidence of end-stage renal disease was the main therapeutic index. Follow-up was conducted for 2 years
Study Type
OBSERVATIONAL
Enrollment
4,472
Dongzhimen Hospital of BeijingUniversity of Chinese Medicine
Beijing, Beijing Municipality, China
Guang'anmen Hospital,China Academy of Chinese Medical Sciencescancel
Beijing, Beijing Municipality, China
The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
The Affiliated Hospital to ChangChun University of Chinese Medicinecancel
Changchun, Jilin, China
Tianjin Medical University Chu Hsien-I Memorial Hospital
Tianjin, Tianjin Municipality, China
The incidence of end-stage renal disease
dialysis, transplantation or glomerular filtration rate ( eGFR ) \< 15ml / ( min · 1.73m2 )
Time frame: Review period, enrollment, enrollment two months, enrollment half a year, enrollment 1 year, enrollment 1 and a half years, enrollment two years
Incidence of renal composite outcome indicators
End-stage renal disease \[ dialysis, transplantation or glomerular filtration rate ( eGFR ) \< 15ml / ( min · 1.73m2 ) \], eGFR decreased by more than 50 %, renal causes of death were defined.
Time frame: Review period, enrollment, enrollment two months, enrollment half a year, enrollment 1 year, enrollment 1 and a half years, enrollment two years
Changes of urinary protein creatinine ratio
Changes of urinary protein creatinine ratio
Time frame: Review period, enrollment, enrollment two months, enrollment half a year, enrollment 1 year, enrollment 1 and a half years, enrollment two years
Changes of 24-hour urinary protein level
Changes of 24-hour urinary protein level
Time frame: Review period, enrollment, enrollment two months, enrollment half a year, enrollment 1 year, enrollment 1 and a half years, enrollment two years
Estimate the change value of glomerular filtration rate ( eGFR ) level, slope
Estimate the change value of glomerular filtration rate ( eGFR ) level, slope
Time frame: Review period, enrollment, enrollment two months, enrollment half a year, enrollment 1 year, enrollment 1 and a half years, enrollment two years
Chinese medicine syndrome scores
The TCM(Traditional Chinese Medicine) symptoms of the patients were scored by the TCM syndrome scale in order to judge the improvement of their symptoms.The highest score was 114 points, and the lowest score was 0 points. The higher the score, the worse the patient 's health.
Time frame: Review period, enrollment, enrollment two months, enrollment half a year, enrollment 1 year, enrollment 1 and a half years, enrollment two years
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