The goal of the Reset trial is to learn about the optimal combination of dietary behavior strategies in a fully digital weight loss intervention. The intervention is designed for adults with overweight or obesity. The investigators will examine the impact on weight loss of four dietary strategies: 1) limiting Red Zone Foods (i.e., foods that are high in calories and low in nutrition), 2) limiting eating windows, 3) increasing protein intake, and 4) increasing fiber intake. Each of these strategies will include goal setting, daily self-monitoring, and tailored feedback. The investigators will recruit 208 participants. Broadly, adults with overweight or obesity who live in the U.S. will be eligible. The weight loss intervention will last 12 weeks. All participants will be asked to track their body weight daily and complete weekly behavioral lessons and action plans to promote healthy eating and physical activity. All study tasks will occur remotely. Assessment of body weight and survey measures will occur at the beginning of the trial ("baseline"), and at 1 month and 3 months. The Multiphase Optimization Strategy (MOST) framework will be used to identify which combination of the dietary behavior strategies results in the greatest weight loss. In total, there will be 16 treatment conditions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
208
All participants receive a 12-week core behavioral weight loss intervention consisting of the following: daily self-monitoring of weight; weekly behavioral lessons and action plans to promote healthy eating and physical activity; and tailored feedback. The intervention will be delivered remotely via email and/or text message.
Participants randomized to receive this component are given a goal to limit their Red Zone Foods (i.e., foods high in calories and low in nutrition) and are instructed to self-monitor them daily.
Participants randomized to receive this component are given a goal to limit their eating windows (i.e., follow time-restricted eating) and are instructed to self-monitor them daily.
Participants randomized to receive this component are given a goal to increase their protein intake and are instructed to self-monitor it daily.
Participants randomized to receive this component are given a goal to increase their fiber intake and are instructed to self-monitor it daily.
Stanford University School of Medicine
Palo Alto, California, United States
Weight Change from Baseline to 3 Months
mean change in kg; assessed via participants' personal scales
Time frame: Baseline and 3 Months
Weight Change from Baseline to 1 Month
mean change in kg; assessed via participants' personal scales
Time frame: Baseline and 1 Month
Clinically Significant Weight Loss at 3 Months
operationalized as the proportion of participants achieving ≥5% weight loss from baseline
Time frame: 3 Months
Moderate-to-Vigorous Physical Activity (MVPA) Change from Baseline to 3 Months
mean change; assessed via the Godin Leisure-Time Exercise Questionnaire (GLTEQ)'s MVPA Score Index. The GLTEQ is a self-report measure that assesses a typical week's frequency of engaging in different types of exercise (strenuous, moderate, mild/light) for at least 15 minutes. Minimum score is 0. Higher scores indicate more frequent exercise. Scores ≥ 24 indicate "active" while scores \< 24 indicate "insufficiently active."
Time frame: Baseline and 3 Months
Caloric Intake Change from Baseline to 3 Months
mean change in kilocalories; assessed via the Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24): 2 separate 24-hour diet recalls per time point: 1 week day, 1 weekend day
Time frame: Baseline and 3 Months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.