The goal of this clinical trial is to investigate the effect of oral hyaluronate in patients with knee osteoarthritis. The main question it aims to answer is: the therapeutic effect in the combined treatment of oral nutritional supplement based on hyaluronic acid with hyaluronic acid intra-articular Injection on symptomatic knee osteoarthritis. Researchers will compare it to those who receive only hyaluronic acid injection to see if the combined treatment is better. Participants will receive a total of three months of oral hyaluronate or placebo agents.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
40
The patient receives oral hyaluronate and hyaluronate injection
The patient receives hyaluronate injection only
Taichung Veterans General Hospital
Taichung, Taiwan, Taiwan
RECRUITINGThe Western Ontario and McMaster Universities Arthritis Index (WOMAC)
The Western Ontario and McMaster Universities Arthritis Index (WOMAC) aim to reveal pain, stiffness and function of the knee, the minimum and maximum values are 0 and 68, and a higher score mean a worse outcome.
Time frame: From enrollment to the end of treatment at 12 weeks
knee strength
knee extension and flexion torque detected by isokinetic machine
Time frame: From enrollment to the end of treatment at 12 weeks
Timed up and go test
the time needed for a patient sits on a chair, stands up walks for 3 meters, and then go back down
Time frame: From enrollment to the end of treatment at 12 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.