The present investigation seeks to determine how varying quantities of Platelet-Rich Fibrin (PRF) membranes influence the repair of both gingival and osseous tissues adjacent to dental implants. A secondary objective is to establish whether the incorporation of PRF contributes to enhanced stability of the soft-tissue cover and more effective retention of alveolar bone over an extended period. Central to the study are two specific inquiries: Does the application of PRF correlate with an increase in the width and thickness of keratinized mucosa surrounding the implant? Is there a dose-response relationship such that the use of multiple PRF layers yields superior maintenance of bone height compared with a single layer or no PRF at all? To address these questions, clinicians will juxtapose three treatment groups: one receiving no PRF, another receiving a single membrane, and a third receiving a triple-layer graft. Healing parameters will be measured before surgery and again at 6-week and 12-week checkpoints, allowing direct appraisal of outcome changes across the comparative cohorts. Each participant will ultimately be allotted to one of the experimental arms by random assignment, thus mitigating selection bias. Routine follow-up examinations and radiographic imaging, will be used to track healing progress.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
31
Standard dental implant placement procedure with flap elevation and suturing, without the application of any PRF membrane over the implant site.
PRF membrane prepared via centrifugation is applied as a single layer over the implant site following implant placement before flap closure.
Three autologous PRF membranes prepared via centrifugation are stacked and applied as a 3-layer membrane over the implant site before flap closure.
University of Mosul / College of Dentistry
Mosul, Nenavah, Iraq
Ridge Width Changes (RW)
The changes in Ridge Width is measured at the reference points using a digital vernier caliper.
Time frame: Baseline (preoperative), immediate postoperative, 6 weeks, and 12 weeks
Bone Width (BW)
Measured in millimeters by subtracting the buccal and lingual mucosal thickness from the ridge width.
Time frame: Baseline (preoperative), and 12 weeks postoperatively
Change in width of keratinized tissue (KTW)
Measured in millimeters at the mid-buccal aspect of the implant site using an endodontic rotary file and digital vernier caliper.
Time frame: Baseline (preoperative), 6 weeks, and 12 weeks
Keratinized Tissue Thickness (KTT)
Measured in millimeters at the buccal, crestal and lingual reference points using a periodontal probe and a digital vernier caliper.
Time frame: Baseline (preoperative), and 12 weeks postoperatively
Radiographic Mucosal Thickness (RT)
Measured in millimeters on periapical radiographs using digital software from the crestal bone level to the crest of crestal oral mucosa 5 mm away from the height distal surface of the adjacent tooth on the mesial side of the implant.
Time frame: Baseline (preoperative), immediate postoperative, 6 weeks, and 12 weeks
Crestal Bone Height (BH)
Measured in millimeters on periapical radiographs using digital software from the second serration on the mesial side of the implant to the crest of the bone.
Time frame: Immediate postoperative, 6 weeks, and 12 weeks
Plaque Index (PI)
O'Leary plaque index
Time frame: Baseline (preoperative), 6 weeks, and 12 weeks
Gingival Index (GI)
Gingival Bleeding Index
Time frame: Baseline (preoperative), 6 weeks, and 12 weeks
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