Skeletal Muscle Mass on Prognosis and Recovery in Clinical Trial

N/AEnrolling By InvitationNCT07034170

National Taiwan University Hospital90 enrolled

Overview

The objective of this research project is to develop an automated muscle mass measurement system based on computed tomography (CT) images using deep learning and artificial intelligence, and to construct a prognostic prediction model for patients who have experienced cardiac arrest and undergone resuscitation. The model will be validated using multicenter registry data and medical imaging. Furthermore, a clinical trial involving core muscle rehabilitation for post-resuscitation patients will be conducted to evaluate both short-term and long-term outcomes, aiming to comprehensively understand the impact of muscle mass on the prognosis of patients after cardiac arrest.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Out of Hospital Cardiac Arrest Inhospital Cardiac Arrest

Interventions

Participants in the intervention group receive an enhanced rehabilitation program, including muscular electrical stimulation, guided active rehabilitation sessions, and structured physical engagement during periods of consciousness. The intervention is designed to promote functional improvement in post-cardiac arrest patients.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Non-traumatic adult patients who experienced sudden cardiac arrest * Achieved sustained return of spontaneous circulation (ROSC) for more than five minutes following successful resuscitation * Admitted to the ICU * Survived beyond 72 hours without successful weaning from mechanical ventilation Exclusion Criteria: * Age under 18 years * Pregnancy * Expected to be weaned from mechanical ventilation within 48 hours * Terminal-stage cancer or unwillingness to receive aggressive treatment * Unavailability of ICU care due to overcrowding in the emergency intensive care unit * Refusal to participate in the study by the patient or family members * Presence of an implanted pacemaker or defibrillator * Open wounds, severe edema, or deep vein thrombosis in the lower limbs * Pre-arrest status limited to wheelchair use or bedridden, unable to ambulate

Skeletal Muscle Mass on Prognosis and Recovery in Clinical Trial

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes