Ketamine vs Ephedrine on Post Spinal Hypotension in Caesarean Delivery

Ain Shams University100 enrolled

Overview

Comparing ketamine and ephedrine to decrease the incidence of post spinal hypotension after caesarean section delivery.

To compare the effect of ketamine versus ephedrine in decreasing the incidence of hypotension in caesarean section delivery a study group including 50 participants will receive ketamine and 50 group will receive ephedrine after the consent and detailed history the two groups will receive preload of 500ml enter acetate then dormicum for sedation then spinal anesthesia will be performed initial blood pressure and heart rate will be measured then every five minutes

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

100

Conditions

Post Spinal Hypotension

Interventions

KetalarDRUG

women receiving sub-anesthetic dose of ketamine of 0.5 mg/kg IV bolus in 3 ml of normal saline.

EphedrineDRUG

women receiving bolus of 15mg of ephedrine

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing Caesarian Section under spinal anesthesia, * Patients aged 18-45 years, * At term (≥37-week gestation), * American Society of Anaesthesiologists (ASA) physical status 1 or 2 Exclusion Criteria: * Pre-eclampsia, * Chronic hypertension, cardiovascular troubles, * Any contraindication to regional anesthesia such as local infection or bleeding disorders, * Any hypersensitivity to ketamine. * Declined informed consent. * American Society of Anaesthesiologists (ASA) physical status lll or lV

Locations (1)

Ainshams University

Cairo, Egypt

Outcomes

Primary Outcomes

Incidence of hypotension post spinal in CS

For ketamine Group: women receiving sub-anesthetic dose of ketamine of 0.5 mg/kg IV bolus in 3 ml of normal saline. ( Reves JG et al,2010 ) * For ephedrine Group: women receiving bolus of 15mg of ephedrine * All the patients will receive 2 mg midazolam IV directly after delivery of the fetus.( Perumal DK et al ) * Heart Rate (HR) and Mean Arterial Blood Pressure (MAP) will be recorded at baseline 5 minutes prior to the intrathecal injection and 5 minutes, 10 minutes, 15 minutes, and 20 minutes after the injection and then every 15 minutes till the end of the operation. * Incidence of hypotension will be recorded which is defined as MAP less than 20% below the baseline or was ≤ 65 mmHg. Incidence of severe hypotension ≤ 50 mmHg will be recorded.

Time frame: From injection till the end of surgery

Data from ClinicalTrials.gov

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