The purpose of this study is to perform an open label feasibility trial of TMS for the treatment of chronic scrotal content pain.
The purpose of this study is to perform an open label feasibility trial of TMS for the treatment of chronic scrotal content pain. Participants will be screened by study staff for contraindications to TMS treatment. TMS will be delivered use the MagVenture TMS machine. TMS will be delivered during 15 minutes per session, 3 sessions each day, for 3 days. A custom developed SMS text EMA system will be used to gather daily data on pain and functioning in study participants.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
50
Resting motor threshold will be established by first finding the area of the motor cortex associated with visible twitch of the right abductor pollicis brevis (APB). Parameter Estimation by Sequential Testing (PEST) will be conducted to quantify resting motor threshold using visible APB twitch. The left dorsolateral prefrontal cortex (DLPFC) will be located using the Beam F3 method and marked with a felt-tipped marker on the scalp. TMS will be delivered over left DLPFC at 110% of resting motor threshold at 10Hz (5-seconds-on; 10-seconds-off) for 15 minutes per session (3000 pulses), 3 sessions each day (30-minute rest in-between sessions), for 3 days (within 5 consecutive days; a total of 27,000 pulses).
Medical University of South Carolina
Charleston, South Carolina, United States
Patient reported pain score on SMS text EMA system
A custom developed SMS text EMA system will be used to gather daily data on pain
Time frame: baseline, and post intervention (0 days, 1 week, 2 weeks, 1 month, 3 months, 6 months)
Patient reported post procedure quality of life as measured on an SMS text EMA system
A custom developed SMS text EMA system will be used to gather daily data on pain
Time frame: baseline, and post intervention (0 days, 1 week, 2 weeks, 1 month, 3 months, 6 months)
Progression to other treatments
Progression to other medical or surgical treatments
Time frame: Within 6 months after completion
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