Enteral Nutrition With L-Carnitine for Cachexia in Non-Small Cell Lung Cancer

Inclusion Criteria: * 1\. Primary lung tumor confirmed by cytology or histology; 2.Meeting the diagnostic criteria for cachexia (with one of the following criteria): 1. Weight loss \>5% in the past 6 months (without active weight loss); 2. Body mass index (BMI) \<20 and weight loss \>2%; 3. Decreased total skeletal muscle index (detected by bioelectrical impedance analysis: \<7.26 kg/m² for males; \<5.45 kg/m² for females) and weight loss \>2%; 3.Age ≥18 years; 4.Patients scheduled to receive or currently undergoing chemotherapy; 5.Patients with an expected survival period ≥3 months; 6.Signed written informed consent and able to comply with the study visit schedule and relevant procedures; 7.Sufficient organ function before the first study treatment (no use of any blood components, leukocyte-elevating drugs, or platelet-elevating drugs within 14 days prior to randomization): <!-- --> 1. Absolute neutrophil count ≥1.5×10⁹/L; 2. Platelet count ≥100×10⁹/L; 3. Hemoglobin \>90 g/L; 4. Serum creatinine \<1.5×upper limit of normal (ULN) or creatinine clearance (CLcr) calculated by the Cockcroft-Gault formula \>50 mL/min; 5. Total bilirubin \<1.5×ULN (for Gilbert syndrome patients, \<3×ULN is acceptable); 6. AST and ALT \<2.5×ULN (for patients with liver metastases, ≤5×ULN); 7. International normalized ratio (INR) or activated partial thromboplastin time (APTT) ≤1.5×ULN, unless the subject is receiving anticoagulant therapy Exclusion Criteria: * 1.Patients scheduled for lung cancer surgery within the next 3 months; 2.Patients with uncontrolled hyperglycemia after adequate treatment; 3.Patients allergic to levocarnitine; 4.Patients with contraindications to enteral nutrition, including but not limited to active gastrointestinal bleeding, complete intestinal obstruction, etc.; 5.Patients with diseases severely affecting digestion and absorption, including but not limited to subtotal gastrectomy, history of intestinal surgery, etc.; 6.Patients with clinically significant cardiovascular and cerebrovascular diseases, including but not limited to: 1. Myocardial infarction or unstable angina within 6 months before the first drug administration; 2. Stroke or transient ischemic attack within 6 months before the first drug administration; 3. Hypertension that cannot be controlled after optimal antihypertensive treatment (systolic blood pressure \>160 mmHg and/or diastolic blood pressure ≥100 mmHg); 4. Patients with clinically significant arrhythmia who have been stable for \>14 days before the first drug administration may be enrolled; 5. Congestive heart failure (New York Heart Association \[NYHA\] functional classification \> Class 3; see Appendix VI for details); 6. Myocarditis; 7.Patients currently participating in interventional clinical research treatment, or who have received other investigational drugs or devices within 4 weeks prior to randomization; 8.Active tuberculosis or tuberculosis requiring medical intervention at the current stage, including but not limited to pulmonary tuberculosis; 9.Patients with known mental illnesses or substance abuse that may affect compliance with trial requirements, or a history of alcohol abuse; 10.Patients with medical history, diseases, treatments, or laboratory abnormalities that may interfere with trial results or prevent the subject from participating in the study throughout the process, or where the investigator deems participation not in the subject's best interest; 11.Local or systemic diseases caused by non-malignant tumors, or secondary reactions to cancer, which may lead to higher medical risks and/or uncertainty in survival evaluation.