Use of Macrolides in Acute Chest Syndrome: A Multicenter Retrospective Study

Centre Hospitalier de Saint-Denis250 enrolled

Overview

This study looks at whether using macrolide antibiotics is helpful and safe in treating acute chest syndrome, a serious complication in people with sickle cell disease. It reviews past cases from three hospitals where patients were treated in intensive care. The goal is to understand if macrolides make a difference, what germs are involved, how useful lab tests are, and how well patients tolerate these antibiotics.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Sickle Cell Disease Acute Chest Syndrome Glucose-6-Phosphate Dehydrogenase Deficiency Anti-Bacterial Agents Macrolides

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patient (≥18 years old). * Diagnosis of acute chest syndrome (ACS). * Hospitalized in an intensive care unit (ICU). * Microbiological sampling performed (e.g., multiplex PCR, sputum culture \[ECBC\], and/or Legionella urinary antigen test). * Received empiric antibiotic therapy including a macrolide. Exclusion Criteria: * Minor patient (\<18 years old). * Acute chest syndrome not requiring ICU admission. * Acute chest syndrome without any attempt at microbiological documentation.

Use of Macrolides in Acute Chest Syndrome: A Multicenter Retrospective Study

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes