Intrauterine inseminations (IUI) are a commonly used technique in assisted reproductive technology (ART) to help women conceive, whether within a couple or as single individuals. However, national success rates remain modest, with an average live birth rate of 10% per cycle, which leads many ART centers to favor in vitro fertilization (IVF) as a more effective option. Nevertheless, IUI retains several advantages: it is less invasive, less expensive, and, when appropriately indicated, can achieve satisfactory outcomes. Guidelines exist for ovarian stimulation protocols prior to IUI, aimed at optimizing the chances of success. So far, no clear superiority has been demonstrated between pharmacological ovulation triggering and spontaneous ovulation. However, accurate timing of insemination in relation to ovulation is recognized as a key factor for success. Very few studies have focused on the response to ovulation triggering, and none have explored a correlation with clinical pregnancy rates. Yet, monitoring of the luteal phase and response to ovulation triggering is a common practice in ART, particularly in the context of frozen embryo transfers (FET), suggesting that these parameters may be worth further investigation in the context of IUI. Hence, the interest of this study is to determine whether there is a correlation between progesterone levels and clinical pregnancy rates in patients undergoing intrauterine insemination (IUI).
This is a single-center observational cohort study with retrospective and prospective data collection. Participation in the study is offered in the CHIC MPA department. Data will be collected over a 12-month period. The research consists of retrieving data from the patient's and spouse's medical records and from software for presenting biological laboratory results . Patients and their spouses will be informed of the study orally, and will receive a written information note.
Study Type
OBSERVATIONAL
Enrollment
158
Chi Creteil
Créteil, CHI Créteil, France
Rate of early pregnancies based on progesterone levels measured on the day of ovulation trigger
Rate of early pregnancies based on progesterone levels measured on the day of ovulation trigger
Time frame: 6-7 weeks Gestational Age
Rate of early pregnancies (HCG > 100) and ultrasound (6-7 weeks gestational age)
Rate of early pregnancies (HCG \> 100) and ultrasound (6-7 weeks gestational age)
Time frame: 6-7 weeks Gestational Age
Rate of spontaneous miscarriage
Rate of spontaneous miscarriage before 12 weeks Gestational Age
Time frame: From enrollment until 12 weeks Gestational Age
Estradiol level the morning of the insemination (pg/ml)
Estradiol level will be collected for each patient The morning of the insemination (between 1 and 4 hours before the insemination)
Time frame: The morning of the insemination (between 1 and 4 hours before the insemination)
LH level the morning of the insemination (UI/L)
LH level will be collected for each patient , the morning of the insemination (between 1 and 4 hours before the insemination)
Time frame: The morning of the insemination (between 1 and 4 hours before the insemination)
hCG level the morning of the insemination (UI/L)
hCG level will be collected for each patient , the morning of the insemination (between 1 and 4 hours before the insemination)and 4 hours before the insemination)
Time frame: The morning of the insemination (between 1 and 4 hours before the insemination)
Progesterone level the morning of the insemination (ng/ml)
Progesterone level will be collected for each patient , the morning of the insemination (between 1 and 4 hours before the insemination)
Time frame: The morning of the insemination (between 1 and 4 hours before the insemination)
Time between first IUI and early pregnancy (HCG > 100 (UI/L)
Time between first IUI and early pregnancy (HCG \> 100 (UI/L)
Time frame: From first IUI until HCG > 100 (UI/L)
Predictive factor for pregnancy: BMI ( kg/m^2)
Predictive factor for pregnancy: BMI
Time frame: From enrollment until the morning of insemination (between 1 and 4 hours before insemination)
Predictive factor for pregnancy:number of inseminated spermatozoa (millions)
Predictive factor for pregnancy: number of inseminated spermatozoa
Time frame: From enrollment until the morning of insemination (between 1 and 4 hours before insemination)
Predictive factor for pregnancy: age (years)
Predictive factor for pregnancy: age
Time frame: From enrollment until the morning of insemination (between 1 and 4 hours before insemination)
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