The purpose of this study is to investigate the absorption, metabolism, excretion, and bioavailability of LY4065967 in healthy male participants. This is a 2-part study. The study will last about 58 days for participants in Part 1 and about 60 days for participants in Part 2.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
16
Fortrea Clinical Research Unit
Madison, Wisconsin, United States
Part 1: Percentage of Total Radioactive Dose in Urine and Fecal Excretion
Time frame: Baseline through Study Completion (21 days)
Part 2: Plasma Area Under the Concentration-time Curve from Zero to Infinity (AUC(0-ꝏ)) for LY4065967
Time frame: Baseline through Study Completion (9 Days)
Part 1 Pharmacokinetic (PK): Plasma AUC(0-ꝏ) for Total Radioactivity and LY4065967
Time frame: Baseline through Study Completion (21 days)
Part 1 PK: Plasma Maximum Concentration (Cmax) for Total Radioactivity and LY4065967
Time frame: Baseline through Study Completion (21 days)
Part 1 PK: Blood Total Radioactivity AUC
Time frame: Baseline through Study Completion (21 days)
Part 1 PK: Blood Total Radioactivity Cmax
Time frame: Baseline through Study Completion (21 days)
Part 1: Total Number and Identification of Metabolites
Time frame: Baseline through Study Completion (21 days)
Part 2 PK: Plasma AUC(0-ꝏ) for Total Radioactivity, [14C]-LY4065967, and LY4065967
Time frame: Baseline through Study Completion (9 Days)
Part 2 PK: Plasma Cmax for Total Radioactivity, [14C]-LY4065967, and LY4065967
Time frame: Baseline through Study Completion (9 Days)
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