Impact of Severe Obstructive Sleep Apnea-Hypopnea Syndrome on Auditory-Cognitive Processing

Peking University First Hospital100 enrolled

Overview

The goal of this observational study is to learn how severe obstructive sleep apnea-hypopnea syndrome (OSAHS) affects the brain's ability to process sounds and attention in adults aged 20-60 years. The main questions it aims to answer are: 1. Does severe OSAHS change how the brain automatically detects sound changes during wakefulness? 2. Does severe OSAHS reduce people's ability to pay attention to important sounds when awake? 3. Can brainwave tests (Electroencephalogram, EEG) detect early signs of hearing-related cognitive problems in OSAHS patients before symptoms appear? Researchers will compare two groups: * 50 adults with severe OSAHS (diagnosed by sleep tests) * 50 healthy adults matched by age and gender Participants will: * Complete hearing tests (MoCA) * Undergo a 1-night sleep test (PSG) * Wear an EEG cap for 1.5-2 hours while listening to sounds in a quiet room: * Passive task: Relax (no response needed) * Active task: Press a button when hearing rare sounds * Receive ¥75/hour compensation for their time

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Obstructive Sleep Apnea Auditory Processing Disorder

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: All Participants: * Aged 20-60 years * Normal hearing (PTA ≤25 dB HL at 0.5,1,2,4 kHz; Type A tympanogram) * MoCA score ≥26 * Willing to complete EEG testing OSAHS Group Additional: \- PSG-confirmed severe OSAHS (AHI \>30 events/hour) Control Group Additional: * Self-reported absence of snoring/sleep disorders * No prior OSAHS diagnosis Exclusion Criteria: All Participants: * History of: * Schizophrenia, epilepsy, Parkinson's, TBI, or language disorders * Middle/inner ear diseases (otitis media, acoustic neuroma, etc.) * Cognitive impairment or depression/anxiety disorders * Chronic steroid use * Systemic inflammatory diseases or malignancies * Pregnancy or suspected pregnancy (self-reported)

Outcomes

Primary Outcomes

Amplitude of Mismatch Negativity (MMN)

EEG-derived MMN amplitude (microvolts, μV) during oddball task. Lower values indicate impaired automatic sound change detection.

Time frame: Day 1

Latency of Mismatch Negativity (MMN)

EEG-derived MMN latency (milliseconds, ms) during oddball task. Longer values indicate slower automatic processing.

Time frame: Day 1

Secondary Outcomes

Reaction Time in Active Auditory Oddball Task

Time taken to press button after deviant sound onset (milliseconds). Higher values indicate slower processing speed.

Time frame: Day 1

Accuracy in Active Auditory Oddball Task

Percentage of correct button presses to deviant sounds (%). Lower values indicate worse performance.

Time frame: Day 1

Inter-Trial Phase Coherence (ITPC) in Theta/Alpha/Beta Bands

EEG oscillatory synchronization (range 0-1; 0=no phase consistency). Lower values indicate neural desynchronization during auditory processing.

Time frame: Day 1

Impact of Severe Obstructive Sleep Apnea-Hypopnea Syndrome on Auditory-Cognitive Processing

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts