Pathogenesis and Inflammatory Phenotype of Allergic Bronchopulmonary Aspergillosis

Qianfoshan Hospital140 enrolled

Overview

This study aims to reveal the immune and inflammatory regulatory molecular mechanisms related to the progression of allergic bronchopulmonary aspergillosis (ABPA), and to build a precision typing based on inflammation and identify the biomarkers of typing, and to explore the clinical outcomes of different inflammatory phenotypes.

Study Type

OBSERVATIONAL

Enrollment

140

Conditions

Allergic Bronchopulmonary Aspergillosis (ABPA)

Interventions

OTHER

No intervention

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Meets the diagnostic criteria for allergic bronchopulmonary aspergillosis. * Meets the diagnostic criteria for fungal-sensitized asthma. Exclusion Criteria: * Human immunodeficiency virus infection. * Malignant tumor. * Blood system disease. * autoimmune system disease. * History of pulmonary tuberculosis. * Patients with a history of smoking or still smoking. * Invasive pulmonary fungal disease. * Contraindications electronic bronchoscopy

Locations (1)

Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, #16766, Jingshi Road, Jinan City, Shandong Province, China

Jinan, Shandong, China

RECRUITING

Outcomes

Primary Outcomes

Total serum IgE

Time frame: Up to 12 months

Secondary Outcomes

Aspergillus-specific IgE

Time frame: Up to 12 months

Aspergillus-specific IgG

Time frame: Up to 12 months

Central Contacts

Qian Qi, Prof.

CONTACT

+86 13706380314 qiqianqlh@163.com

Data from ClinicalTrials.gov

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