The aim of the study is to evaluate and compare the effectiveness of extended platelet-rich fibrin (ePRF) alone and in combination with bioactive glass nanoparticles in the treatment of grade II furcation defects clinically and radiographically.
A total of 30 grade II furcation defects will be randomly divided into three groups as follows: Group I: 10 grade II furcation defects will be treated by extended platelet-rich fibrin (ePRF) alone. Group II: 10 grade II furcation defects will be treated by bioactive glass nanoparticles mixed with extended platelet-rich fibrin (BGn+ePRF). Group III: 10 grade II furcation defects will be treated by bioactive glass nanoparticles with collagen membrane.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
30
mucoperiosteal flap will be raised through sulcular incisions Debridement of granulation tissue from the osseous defect and furcation will be filled with (ePRF) at the first group
bioactive glass nanoparticles mixed with extended platelet-rich fibrin (BGn+ePRF)
bioactive glass nanoparticles and covered by a collagen membrane
Mansoura University
Al Mansurah, Egypt
The primary outcome will be the amount of bone fill vertically and horizontally obtained in the treatment of grade II furcation defects calculated from CBCT data in millimeters
Time frame: 6 months follow up
the secondary outcomes include improvements (decrease)of probing depth in millimetres
Using UNC-15 periodontal probe to measure the probing depth from the base of the pocket to the free gingival margin. All measurements will be rounded off to the nearest millimetre.
Time frame: 3 and 6 months follow up
the secondary outcomes include improvements (decrease)of clinical attachment level loss in millimetres
using a UNC-15 periodontal probe to measure clinical attachment level loss from the cemento-enamel junction (CEJ) to the pocket depth. All measurements will be rounded off to the nearest millimetre
Time frame: 3 and 6 months follow up
the secondary outcomes include improvements (decrease) of gingival recession measured in millimetres
Using a UNC-15 periodontal probe to measure gingival recession from cemento-enamel junction (CEJ) to the free gingival margin. All measurements will be rounded off to the nearest millimetre
Time frame: 3 and 6 months follow up
the secondary outcomes include improvements (decrease) of gingival bleeding index
It's performed through gentle probing of the orifice of the gingival crevice using a UNC-15 periodontal probe. If bleeding occurs within 10 seconds a positive finding is recorded, and the number of positive sites is recorded and then expressed as a percentage of the number of the sites examined.
Time frame: 3 and 6 months follow up
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