Effects of Pulmonary Resection on Right Ventricular Function

Çağrı Özdemir33 enrolled

Overview

Lung resection is associated with high postoperative morbidity and mortality and leads to a significant long-term decrease in functional capacity, particularly due to cardiorespiratory complications. One of the contributing factors to this functional decline is the postoperative reduction in right ventricular function. Due to the anatomical proximity and interactions, right ventricular function is evaluated by echocardiography following lung resection. The pulmonary artery pressure (PAP)/tricuspid annular plane systolic excursion (TAPSE) ratio is a parameter that provides a more comprehensive assessment of right heart function by evaluating both right ventricular systolic function and pulmonary artery pressure. In this study, investigators aimed to evaluate changes in right heart function by performing preoperative and postoperative echocardiographic assessments in participants undergoing lung resection, focusing on PAP/TAPSE ratios.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pulmonary Resection Right Ventricular Function Echocardiography Cardiothoracic Anesthesia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Adults aged 18 to 80 years ASA classification I-III Patients scheduled to undergo lung resection in thoracic surgery Exclusion Criteria: Patients with arrhythmia Patients using antiarrhythmic drugs Patients with renal failure requiring hemodialysis Patients with a history of previous lung surgery Patients with valvular heart disease Patients with a history of angina pectoris or myocardial infarction within the past month Patients with FEV1/FVC ratio below 60%

Outcomes

Primary Outcomes

Echocardiographic Assessment: TAPSE/PASP Ratio

Patients will undergo transthoracic echocardiographic evaluation preoperatively, on postoperative days 2-4, and at postoperative month 2. The TAPSE/PASP ratio will be calculated and recorded in mm/mmHg as a non-invasive surrogate of right ventricular-pulmonary arterial coupling.

Time frame: Preoperatively, on postoperative days 2-4, and at postoperative month 2

Echocardiographic Assessment: Tricuspid Annular Plane Systolic Excursion (TAPSE)

Patients will undergo transthoracic echocardiographic evaluation preoperatively, on postoperative days 2-4, and at postoperative month 2. TAPSE will be measured and recorded in millimeters (mm).