The main objective of the study is to assess the relative bioavailability of KAI-9531 subcutaneous (SC) injection in the upper arm and thigh compared to the abdomen.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
51
SC Injection.
Celerion
Tempe, Arizona, United States
Maximum Observed Concentration (Cmax) of KAI-9531
Time frame: Treatment Period 1, 2 and 3: Pre-dose and up to 672 hours post-dose
Area Under the Concentration-time Curve From 0 to Time of Last Quantifiable Concentration (AUC0-t) of KAI-9531
Time frame: Treatment Period 1, 2 and 3: Pre-dose and up to 672 hours post-dose
Area Under the Concentration-time Curve From 0 to Infinity (AUC0-inf) of KAI-9531
Time frame: Treatment Period 1, 2 and 3: Pre-dose and up to 672 hours post-dose
Number of Participants Who Experience a Treatment-emergent Adverse Event (TEAE)
Time frame: Day 1 to Day 113
Number of Participants Who Experience a Serious Adverse Event (SAE)
Time frame: Day 1 to Day 113
Number of Participants Who Experience Antidrug Antibodies to KAI-9531
Time frame: Day 1 to Day 113
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