The aim of this clinical trial is to study the effect of transcutaneous electrical acupoint stimulation combined with auricular vagus nerve stimulation on postoperative delirium in elderly patients undergoing gastrointestinal surgery. The study aims to answer the following main questions 1. whether it reduces the expression of inflammatory factors in the acute postoperative period 2. whether it can reduce the incidence of postoperative delirium
Existing clinical studies have shown that TEAS has demonstrated value in preventing postoperative delirium (POD). Currently, taVNS is commonly used clinically to improve patients' cognitive dysfunction (POCD), and POD is often considered a precursor to the development of POCD. However, no one has yet used the two in combination, so this study aimed to combine the two to investigate their potential benefits in preventing POD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
116
Before induction of anaesthesia, electrodes were attached to selected acupoints and energised for 30 min, with the electrical stimulation parameter of dispersed dense wave (2/100 Hz), and the current intensity was based on the maximum current intensity that could be tolerated by the patient.
Before anaesthesia induction, the electrodes were attached to the selected acupoints and energized for 30 min, with the electrical stimulation parameters of dispersed dense wave (2/100Hz), and the current intensity was based on the maximum current intensity that the patient could tolerate. At the same time, the left ear auricular region was stimulated with a fasciculus nerve stimulator, the electrical stimulation parameters were: pulse width of 250 μs, pulse frequency of 20Hz, every 30s on, 30s off, and then 30s on again, the current intensity was based on the maximum current intensity that the patient could tolerate, for 30min.
Affiliated Hospital Nantong University
Nantong, Jiangsu, China
Incidence of postoperative delirium
Whether delirium occurred after surgery(by 3D-CAM)
Time frame: The first to third days after surgery
IL-6 andTNF-α level
the level of IL-6 andTNF-α in the participant's serum(by ELISA)
Time frame: before operation(Before anesthesia),the end of the operation(Immediately after the sewing is finished)
VAS pain score
Assessed with a VAS score scale, the highest is 10 and the lowest is 0, the higher the more severe the pain
Time frame: The first to third days after surgery
Early activities
The first time to be able to get out of bed and move
Time frame: Post-operative period until discharge(in about a week)
Time to first postoperative anal defecation
Time to first postoperative anal defecation
Time frame: Post-operative period until discharge(In about a week)
Adverse events
Nausea and vomiting, sore throat, itching
Time frame: The first to third days after surgery
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