Assessment the Effectiveness of BTVA in COPD and Ablation in Pulmonary Nodules by Pulmonary MRI

Shanghai Chest Hospital100 enrolled

Overview

A Clinical Study Based on Magnetic Resonance Imaging of the Lungs to Assess the Efficacy of Thermal Vapor Ablation and Pulmonary Nodule Ablation in Chronic Obstructive Pulmonary Disease After Surgery. The efficacy of hot steam ablation for chronic obstructive pulmonary disease was evaluated using the innovative MRI sequence PREFUL\_MRI, and the efficacy of pulmonary nodule ablation was evaluated using the innovative MRI sequence GRASP\_MRI.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

COPD Lung Cancers

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age \>18 years old; 2. Patients with pulmonary nodules: patients with pulmonary nodules indicated by chest CT, pathologically diagnosed as malignant, and receiving ablative treatment, including transthoracic and percutaneous ablative methods, including radiofrequency, microwave, and freezing; 3. COPD patients: patients diagnosed with COPD according to the GOLD principle and treated with thermal steam ablation for COPD; 4. Understand the study and sign the informed consent. Exclusion Criteria: 1. Chest CT nodules in patients with pulmonary nodules were pure ground glass nodules; 2. Patients who install or carry metal implants such as cardiac pacemakers, heart stents, artificial heart valves in the body or suffer from claustrophobia, allergy to contrast media and other reasons are not suitable for MRI examination; 3. severe cardiopulmonary dysfunction and other diseases that may significantly increase the risk of ablation surgery; 4. Patients with severe COPD exacerbation or pneumonia in the past four weeks;

Locations (1)

Shanghai chest hospital

Shanghai, Shanghai Municipality, China

RECRUITING

Outcomes

Primary Outcomes

PREFUL-MRI Ventilation and Perfusion Parameters in Patients with COPD Following Lung Volume Reduction Surgery with Thermal Steam

Using the Phase-Resolved Functional Lung(PREFUL)-MRI dedicated post-processing analysis software, we can obtain images of the patient's lung ventilation and perfusion status.

Time frame: From enrollment to 6 months post-surgery

PREFUL-MRI Ventilation and Perfusion Parameters in Patients with COPD Following Lung Volume Reduction Surgery with Thermal Steam

Percentage of perfusion defect (QDP)：Calculation of QDP based on PREFUL-MRI dedicated post-processing software

Time frame: From enrollment to 6 months post-surgery

PREFUL-MRI Ventilation and Perfusion Parameters in Patients with COPD Following Lung Volume Reduction Surgery with Thermal Steam

Percentage of ventilation defect (VDP)：Calculation of VDP based on PREFUL-MRI dedicated post-processing software

Time frame: From enrollment to 6 months post-surgery

PREFUL-MRI Ventilation and Perfusion Parameters in Patients with COPD Following Lung Volume Reduction Surgery with Thermal Steam

Percentage of ventilation-perfusion match (VQM):Calculation of VQM based on PREFUL-MRI dedicated post-processing software

Time frame: From enrollment to 6 months post-surgery

Quantitative Hemodynamic Analysis Parameters Based on Tofts Model Using GRASP-MRI After Ablation of Solid Pulmonary Nodules

Quantitative parameters of GRASP-MRI images based on the Tofts model: Volume transfer coefficient(Ktrans)(/min)：the rate transfer constant of gadolinium between plasma and tissue interstitium;

Time frame: From enrollment to 3 months post-surgery

Quantitative Hemodynamic Analysis Parameters Based on Tofts Model Using GRASP-MRI After Ablation of Solid Pulmonary Nodules

Central Contacts

Lin Ye, MD

CONTACT

021-62821990 sjtuyl@163.com

Jiayuan Sun, MD, PhD

CONTACT

021-62821990 xkyyjysun@163.com

Data from ClinicalTrials.gov

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