Exploration and Establishment of an Early Warning System for Futile Reperfusion - A I S

N/AEnrolling By InvitationNCT07045987

Xijing Hospital2,000 enrolled

Overview

The goal of this prospective cohort registration study is to establish an early warning system for futile recanalization in acute ischemic stroke by analyzing multi-omics information to identify key regulatory nodes and target molecules in ineffective recanalization. The core issue addressed by this research is: Identifying key regulatory nodes and target molecules closely associated with futile recanalization, revealing the interactions among the neurovascular unit, peripheral immune cells, and the brain lymphatic system, as well as developing early diagnostic biomarkers and novel diagnostic technologies for futile recanalization.

Study Type

OBSERVATIONAL

Enrollment

2,000

Conditions

Acute Ischemic Stroke (AIS)Endovascular Thrombectomy Neurovascular Unit- Brain Lymphatic System

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 1\. Aged ≥18 years 2. Acute ischemic stroke confirmed by clinical and neuroimaging criteria (CT or MRI) 3. Clinical indication for thrombectomy 4. Provision of signed informed consent Exclusion Criteria: * 1\. Preexisting dementia or severe disability (modified Rankin Scale score ≥3) 2. Cerebral vascular malformations, neoplasms, abscesses, or other significant non-ischemic brain pathologies 3. Life-limiting systemic comorbidities (e.g., end-stage organ failure, metastatic malignancies) with anticipated survival \<6 months 4. Patient or legally authorized representative declined consent 5. Anticipated poor protocol adherence or loss to follow-up

Exploration and Establishment of an Early Warning System for Futile Reperfusion - A I S

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes