Effects os Physiotherapeutic Rehabilitation on Function Autonomic and Inflammatory in Patients With Long Covid

N/ANot Yet RecruitingNCT07046208

Universidade do Estado do Pará58 enrolled

Overview

Introduction: Long COVID is characterized by persistent symptoms that persist for weeks or months after the acute phase of infection, with a significant impact on the cardiovascular and autonomic systems. Objectives: This study aims to evaluate the effects of a physiotherapeutic rehabilitation protocol on cardiovascular autonomic modulation and on inflammatory and cardiac biomarkers in patients with Long COVID. Methodology: This is a controlled clinical trial, carried out in a cardiorespiratory rehabilitation outpatient clinic, involving individuals with a clinical diagnosis of Long COVID undergoing a protocol of 20 aerobic, anaerobic and respiratory rehabilitation sessions. Heart rate variability (HRV) variables will be analyzed using linear and non-linear methods, in addition to serum levels of CKMB, LDH, ferritin and C-reactive protein. Expected results: Rehabilitation is expected to provide an improvement in autonomic function and a reduction in inflammatory and cardiac markers, contributing to the understanding of the pathophysiological mechanisms of Long COVID and helping to propose evidence-based therapeutic strategies.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Long COVID Heart Rate Variability (HRV)

Interventions

physiothreapy protocolOTHER

Aerobic training (treadmill or exercise bike) for 15 minutes, anaerobic training at the weight training station, performing exercises for the upper limbs (bench press and front pull) and lower limbs (180º leg press and extension chair) with weight determined by the 1 Repetition Maximum (1RM) test, performing 3 sets of 12-15 repetitions (depending on the session) and respiratory muscle training using POWERbreathe (30-40% of the MIP performed in the manovacuometry test).

Eligibility

Sex: ALLMin age: 20 YearsMax age: 59 Years

Medical Language ↔ Plain English

Inclusion Criteria: * both sexes * aged 20 and 59 years * clinical evaluation and undergoing clinical follow-up of Post COVID-19. * least one persistent COVID-19-related symptom. Exclusion Criteria: * incomplete data. * presence of a pacemaker * use of antihypertensive drugs that alter HRV * persistent pulmonary alterations * persistent desaturation * anaemia or presence of reinfection.

Outcomes

Primary Outcomes

Autonomic Modulation

cardiofrequency meter

Time frame: Before and afther the intervention 3 months.

Secondary Outcomes

Inflammation

the cardiac and inflammatory biomarkers, creatine phosphokinase isoenzyme MB (CKMB) associated with lactate dehydrogenase (LDH) and ferritin can be analysed.

Time frame: Before and the afther 3 months