The effectiveness and efficacy of the combination of pharmacotherapy with the two new recovery-oriented programs, RECOVERYTRSGR for patients with treatment- resistant schizophrenia and RECOVERYTRSBDGR for patients with treatment- resistant bipolar disorder.
RECOVERYTRSGR is a newly developed program for patients with treatment resistant schizophrenia by Dr. S. Rakitzi and Dr. P. Georgila. RECOVERYTRSBDGR is a newly developed program for patients with treatment resistant bipolar disorder by Dr. S. Rakitzi and Dr. P. Georgila. These programs offer a long term combination of pharmacotherapy and cognitive behavioral psychotherapy and rehabilitation and aim to imrove cognition, symptoms, functional outcomes and recovery. Treatment resistant schizophrenia and treatment resistant bipolar disorder are the most difficult chronic mental health disorders which need long-term treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
40
A combination of pharmacotherapy (antipsychotics, anxiolytics, antidepressants) with RECOVERYTRSGR (psychotherapy) for patients with treatment-resistant schizophrenia. 190 sessions. 22 patients
The combination of pharmacotherapy (antipsychotics, anxiolytics, antidepressants) and TAU (psychotherapy) for patients with treatment-resistant schizophrenia. 190 sessions. The control group of Group A 20 patients
Private practice of Dr. S. Rakitzi and Dr. P. Georgila ILISION 34 15771 ATHENS GREECE
Athens, Greece
RECRUITINGMCCB BACS symbol coding (for RECOVERYTRSGR)
It measures speed of processing. Minimum 0, maximum 110, high scores better
Time frame: Pre-intervention
MCCB BACS symbol coding (for RECOVERYTRSGR)
It measures speed of processing. Minimum 0, maximum 110, high scores better
Time frame: Immediately after the intervention
MCCB BACS symbol coding (for RECOVERYTRSGR)
It measures speed of processing. Minimum 0, maximum 110, high scores better
Time frame: Follow-up up to 24 weeks
MCCB Wechsler memory scale-spatial span (for RECOVERYTRSGR)
It measures non-verbal working memory. Minimum 0, maximum 32, high scores better, Summary of forward and backward total score.
Time frame: Pre-intervention
MCCB Wechsler memory scale-spatial span (for RECOVERYTRSGR)
It measures non-verbal working memory. Minimum 0, maximum 32, high scores better. Summary of forward and backward total score
Time frame: Immediately after the intervention
MCCB Wechsler memory scale-spatial span (for RECOVERYTRSGR)
It measures non-verbal working memory. Minimum 0, maximum 32, high scores better. Summary of forward and backward total score
Time frame: Follow-up up to 24 weeks
MCCB Neurospychological Assessment Battery (NAB) (for RECOVERYTRSGR)
It measures reasoning and problem-solving. Minimum 0, maximum 26. high scores better
Time frame: Pre-intervention
MCCB Neurospychological Assessment Battery (NAB) (for RECOVERYTRSGR)
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A combination of pharmacotherapy with RECOVERYTRSBDGR (antipsychotics, anxiolytics, antidepressants, mood stabilizers) for patients with treatment-resistant bipolar disorder. 140 sessions, 22 people
A combination of pharmacotherapy (antipsychotics, anxiolytics, antidepressants, mood stabilizers) and TAU (psychotherapy). A control group to RECOVERYTRSBDGR. 140 sessions. 20 people
It measures reasoning and problem-solving. Minimum 0, maximum 26. high scores better
Time frame: Immediately after the intervention
MCCB Neurospychological Assessment Battery (NAB) (for RECOVERYTRSGR)
It measures reasoning and problem-solving. Minimum 0, maximum 26. high scores better
Time frame: Follow-up up to 24 weeks
MCCB Brief visuospatial memory test (for RECOVERYTRSGR)
It measures visual memory. Sum of Trial 1, 2, 3. Minimum 0, maximum 12. high scores better.
Time frame: Pre-intervention
MCCB Brief visuospatial memory test (for RECOVERYTRSGR)
It measures visual memory. Sum of Trial 1, 2, 3. Minimum 0, maximum 12. high scores better.
Time frame: Immediately after the intervention
MCCB Brief visuospatial memory test (for RECOVERYTRSGR)
It measures visual memory. Sum of Trial 1, 2, 3. Minimum 0, maximum 12. high scores better.
Time frame: Follow-up up to 24 weeks
Social Perception Scale (SPS) Stimuli (for RECOVERYTRSGR)
It measures social cognition. Minimum 0, maximum 67. high scores better.
Time frame: Pre-intervention
Social Perception Scale (SPS) Stimuli (for RECOVERYTRSGR)
It measures social cognition. Minimum 0, maximum 67. high scores better.
Time frame: Immediately after the intervention
Social Perception Scale (SPS) Stimuli (for RECOVERYTRSGR)
It measures social cognition. Minimum 0, maximum 67. high scores better.
Time frame: Follow-up up to 24 weeks
Social Perception Scale (SPS) Interpretation (for RECOVERYTRSGR)
It measures social cognition. Minimum 0, maximum 12. high scores better.
Time frame: Pre-intervention
Social Perception Scale (SPS) Interpretation (for RECOVERYTRSGR)
It measures social cognition. Minimum 0, maximum 12. high scores better.
Time frame: Immediately after the intervention
Social Perception Scale (SPS) Interpretation (for RECOVERYTRSGR)
It measures social cognition. Minimum 0, maximum 12. high scores better.
Time frame: Follow-up up to 24 weeks
Social Perception Scale (SPS) Title (for RECOVERYTRSGR)
It measures social cognition. Minimum 0, maximum 12. high scores better.
Time frame: Pre-intervention
Social Perception Scale (SPS) Title (for RECOVERYTRSGR)
It measures social cognition. Minimum 0, maximum 12. high scores better.
Time frame: Immediately after the intervention
Social Perception Scale (SPS) Title (for RECOVERYTRSGR)
It measures social cognition. Minimum 0, maximum 12. high scores better.
Time frame: Follow-up up to 24 weeks
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSGR)
It measures oral verbal memory. Semantic. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Pre-intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSBDGR)
It measures oral verbal memory. Semantic. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Pre-intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSGR)
It measures oral verbal memory. Semantic. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Immediately after the intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSBDGR)
It measures oral verbal memory. Semantic. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Immediately after the intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSGR)
It measures oral verbal memory. Semantic. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Follow-up up to 24 weeks
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSBDGR)
It measures oral verbal memory. Semantic. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Follow-up up to 24 weeks
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSGR)
It measures oral verbal memory. Phonological. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Pre-intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSBDGR)
It measures oral verbal memory. Phonological. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Pre-intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSGR)
It measures oral verbal memory. Phonological. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Immediately after the intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSBDGR)
It measures oral verbal memory. Phonological. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Immediately after the intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSGR)
It measures oral verbal memory. Phonological. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Follow-up up to 24 weeks
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSBDGR)
It measures oral verbal memory. Phonological. Sum of the 3 categories divided to 3. Minimum 0, maximum 40. high scores better.
Time frame: Follow-up up to 24 weeks
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSGR)
It measures written verbal memory. Sum of the 2 tasks. Minimum 0, maximum as much as possible. high scores better.
Time frame: Pre-intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSBDGR)
It measures written verbal memory. Sum of the 2 tasks. Minimum 0, maximum as much as possible. high scores better.
Time frame: Pre-intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSGR)
It measures written verbal memory. Sum of the 2 tasks. Minimum 0, maximum as much as possible. high scores better.
Time frame: Immediately after the intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSBDGR)
It measures written verbal memory. Sum of the 2 tasks. Minimum 0, maximum as much as possible. high scores better.
Time frame: Immediately after the intervention
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSGR)
It measures written verbal memory. Sum of the 2 tasks. Minimum 0, maximum as much as possible. high scores better.
Time frame: Follow-up up to 24 weeks
The Greek verbal memory test (Kosmidou & Vlahou, 2010) (for RECOVERYTRSBDGR)
It measures written verbal memory. Sum of the 2 tasks. Minimum 0, maximum as much as possible. high scores better.
Time frame: Follow-up up to 24 weeks
PANNS total (for RECOVERYTRSGR)
It measures positive, negative symptoms and general psychopathology. Minimum 31, maximum 210. Low scores better
Time frame: Pre-intervention
PANNS total (for RECOVERYTRSGR)
It measures positive, negative symptoms and general psychopathology. Minimum 31, maximum 210. Low scores better
Time frame: Immediately after the intervention
PANNS total (for RECOVERYTRSGR)
It measures positive, negative symptoms and general psychopathology. Minimum 31, maximum 210. Low scores better
Time frame: Follow-up up to 24 weeks
WHODAS total (for RECOVERYTRSGR)
It measures functional outcome. Minimum 0, maximum 100. low scores better.
Time frame: Pre-intervention
WHODAS total (for RECOVERYTRSGR)
It measures functional outcome. Minimum 0, maximum 100. low scores better.
Time frame: Immediately after the intervention
WHODAS total (for RECOVERYTRSGR)
It measures functional outcome. Minimum 0, maximum 100. low scores better.
Time frame: Follow-up up to 24 weeks
RAS-DS total (for RECOVERYTRSGR)
It measures recovery. Minimum 0, maximum 152. High scores better.
Time frame: Pre-intervention
RAS-DS total (for RECOVERYTRSGR)
It measures recovery. Minimum 0, maximum 152. High scores better.
Time frame: Immediately after the intervention
RAS-DS total (for RECOVERYTRSGR)
It measures recovery. Minimum 0, maximum 152. High scores better.
Time frame: Follow-up up to 24 weeks
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSGR)
It measures severity of illness. Minimum 0, Maximum 7, low scores better.
Time frame: Pre-intervention
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSGR)
It. measures severity of illness. Minimum 0, Maximum 7, low scores better.
Time frame: Immediately after the intervention
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSGR)
It. measures severity of illness. Minimum 0, Maximum 7, low scores better.
Time frame: Follow-up up to 24 weeks
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSGR)
It measures global improvement. Minimum 0, Maximum 7, low scores better.
Time frame: Pre-intervention
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSGR)
It measures global improvement. Minimum 0, Maximum 7, low scores better.
Time frame: Immediately after the intervention
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSGR)
It measures global improvement. Minimum 0, Maximum 7, low scores better.
Time frame: Follow-up up to 24 weeks
SRSDA (for RECOVERYTRSBDGR)
It measures Depression. Minimum 0, maximum 14 or higher. Low scores better
Time frame: Pre-intervention
SRSDA (for RECOVERYTRSBDGR)
It measures Depression. Minimum 0, maximum 14 or higher. Low scores better
Time frame: Immediately after the intervention
SRSDA (for RECOVERYTRSBDGR)
It measures Depression. Minimum 0, maximum 14 or higher. Low scores better
Time frame: Follow-up up to 24 weeks
SRSDA (for RECOVERYTRSBDGR)
It measures Anxiety. Minimum 0, maximum 10 or higher. Low scores better
Time frame: Pre-intervention
SRSDA (for RECOVERYTRSBDGR)
It measures Anxiety. Minimum 0, maximum 10 or higher. Low scores better
Time frame: Immediately after the intervention
SRSDA (for RECOVERYTRSBDGR)
It measures Anxiety. Minimum 0, maximum 10 or higher. Low scores better
Time frame: Follow-up up to 24 weeks
Hamilton Depression Scale (for RECOVERYTRSBDGR)
It measures depression. Minimum 0, maximum 23. Low scores better.
Time frame: Pre-intervention
Hamilton Depression Scale (for RECOVERYTRSBDGR)
It meaasures depression. Minimum 0, maximum 23. Low scores better.
Time frame: Immediately after the intervention
Hamilton Depression Scale (for RECOVERYTRSBDGR)
It meaasures depression. Minimum 0, maximum 23. Low scores better.
Time frame: Follow-up up to 24 weeks
Montgomery and Asperg depression scale (for RECOVERYTRSBDGR)
It measures depression. Minimum 0, maximum 60. Low scores better.
Time frame: Pre-intervention
Montgomery and Asperg depression scale (for RECOVERYTRSBDGR)
It measures depression. Minimum 0, maximum 60. Low scores better.
Time frame: Immediately after the intervention
Montgomery and Asperg depression scale (for RECOVERYTRSBDGR)
It measures depression. Minimum 0, maximum 60. Low scores better.
Time frame: Follow-up up to 24 weeks
The Altman self-rating scale (for RECOVERYTRSBDGR)
It measures mania. Minimum 0, maximum 6 or higher. Low scores better.
Time frame: Pre-intervention
The Altman self-rating scale (for RECOVERYTRSBDGR)
It measures mania. Minimum 0, maximum 6 or higher. Low scores better.
Time frame: Immediately after the intervention
The Altman self-rating scale (for RECOVERYTRSBDGR)
It measures mania. Minimum 0, maximum 6 or higher. Low scores better.
Time frame: Follow-up up to 24 weeks
PSYRAT (for RECOVERYTRSBDGR)
It measures psychotic symptoms. Hallucinations. Minimum 0, maximum 44. Low scores better.
Time frame: Pre-intervention
PSYRAT (for RECOVERYTRSBDGR)
It measures psychotic symptoms. Hallucinations. Minimum 0, maximum 24. Low scores better.
Time frame: Immediately after the intervention
PSYRAT (for RECOVERYTRSBDGR)
It measures psychotic symptoms. Hallucinations. Minimum 0, maximum 24. Low scores better.
Time frame: Follow-up up to 24 weeks
PSYRAT (for RECOVERYTRSBDGR)
It measures psychotic symptoms. Delusions. Minimum 0, maximum 44. Low scores better.
Time frame: Pre-intervention
PSYRAT (for RECOVERYTRSBDGR)
It measures psychotic symptoms. Delusions. Minimum 0, maximum 44. Low scores better.
Time frame: Immediately after the intervention
PSYRAT (for RECOVERYTRSBDGR)
It measures psychotic symptoms. Delusions. Minimum 0, maximum 24. Low scores better.
Time frame: Follow-up up to 24 weeks
WHODAS total (for RECOVERYTRSBDGR)
It measures functional outcome. Minimum 0, maximum 100. Low scores better.
Time frame: Pre-intervention
WHODAS total (for RECOVERYTRSBDGR)
It measures functional outcome. Minimum 0, maximum 100. Low scores better.
Time frame: Immediately after the intervention
WHODAS total (for RECOVERYTRSBDGR)
It measures functional outcome. Minimum 0, maximum 100. Low scores better.
Time frame: Follow-up up to 24 weeks
RAS-DS Total (for RECOVERYTRSBDGR)
It measures recovery. Minimum 0, maximum 152. High scores better
Time frame: Pre-intervention
RAS-DS Total (for RECOVERYTRSBDGR)
It measures recovery. Minimum 0, maximum 152. High scores better
Time frame: Immediately after the intervention
RAS-DS Total (for RECOVERYTRSBDGR)
It measures recovery. Minimum 0, maximum 152. High scores better
Time frame: Follow-up up to 24 weeks
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSBDGR)
It measures severity of illness. Minimum 0, Maximum 7, low scores better.
Time frame: Pre-intervention
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSBDGR)
It measures severity of illness. Minimum 0, Maximum 7, low scores better.
Time frame: Immediately after the intervention
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSBDGR)
It measures severity of illness. Minimum 0, Maximum 7, low scores better.
Time frame: Follow-up up to 24 weeks
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSBDGR)
It measures global improvement. Minimum 0, Maximum 7, low scores better.
Time frame: Pre-intervention
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSBDGR)
It measures global improvement. Minimum 0, Maximum 7, low scores better.
Time frame: Immediately after the intervention
The Clinical Global Impression Scale (CGI) (for RECOVERYTRSBDGR)
It measures global improvement. Minimum 0, Maximum 7, low scores better.
Time frame: Follow-up up to 24 weeks
The Young mania rating scale (for RECOVERYTRSBDGR)
It measures mania. Minimum 0, maximum 60. Low scores better
Time frame: Pre-intervention
The Young mania rating scale (for RECOVERYTRSBDGR)
It measures mania. Minimum 0, maximum 60. Low scores better
Time frame: Immediately after the intervention
The Young mania rating scale (for RECOVERYTRSBDGR)
It measures mania. Minimum 0, maximum 60. Low scores better
Time frame: Follow-up up to 24 weeks
WAIS (for RECOVERYTRSGR)
It measures the Intelligenz-quotient
Time frame: Pre-intervention
WAIS (for RECOVERYTRSBDGR)
It measures the Intelligenz-quotient
Time frame: Pre-intervention