Hypoxemia refers to low blood oxygen levels, while hypoxia denotes low tissue oxygen levels. Both conditions pose life-threatening risks when precautions are not adequately taken or when risks are not effectively managed. Intubation represents a critical phase that can lead to a decrease in arterial oxyhemoglobin levels. Two frequently employed techniques for preoxygenation and ventilation during intubation are bag-valve mask (BVM) ventilation and noninvasive mechanical ventilation (NIMV). The aim of this study was to evaluate the efficacy and safety of BMV and the NIMV.
Ventilation and intubation challenges increase the risk of arterial desaturation, emphasizing the importance of careful management during this process. Throughout the intubation process, the oxygen reserves within the lung, plasma, hemoglobin, body mass index (BMI) play a critical role in meeting the tissue oxygen demand. Preoxygenation serves to extend the time window for intubation safely. The quantity of available oxygen reserve and the duration of the apneic period represent the primary determinants for the occurrence of hypoxemia during intubation. Anticipating difficult intubation is crucial, as it often prolongs both the duration of intubation and the apneic period. The Intubation Difficulty Scale (IDS) is commonly utilized to predict the likelihood of encountering difficult intubation scenarios. It is imperative to select the appropriate preoxygenation technique, particularly in patients with a high IDS, to mitigate the risk of desaturation during the intubation process. Two frequently employed techniques for preoxygenation and ventilation during intubation are BVM ventilation and NIMV. Preoxygenation, also referred to as denitrogenation, has the potential to induce atelectasis. However, this complication can be mitigated with positive pressure ventilation (PPV), which not only aids in maintaining oxygen levels but also exerts effects on the circulatory system. Hypotension is the most common symptom that occurs as a result of the interaction of the respiratory and circulatory systems. The objective of this study was to evaluate and compare the impacts of preoxygenation with BVM and NIMV techniques on oxygenation and hemodynamic parameters specifically during the apneic period of endotracheal intubation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
A BVM equipped with an oxygen reservoir, coupled with a correctly fitted oronasal mask was used.
Preoxygenation was conducted over a three-minute period using NIMV employing a properly fitted oronasal mask. This was facilitated by a mechanical ventilator operating in pressure support mode. The preoxygenation protocol entailed the administration of 100% FiO2, applying Positive End-Expiratory Pressure set at 5 cmH2O, delivering breaths at a frequency of 15 per minute, and providing a tidal volume ranging between 6 to 8 ml/kg of body weight.
Baskent University
Adana, Yuregır, Turkey (Türkiye)
Change in partial pressure of oxygen in arterial blood (PaO₂) values after 3 minutes of preoxygenation
To compare PaO₂ between study groups after 3 minutes of preoxygenation (Unit of Measure: mmHg)
Time frame: At the end of 3 minutes of preoxygenation
Change in partial pressure of carbon dioxide in arterial blood (PaCO₂) values after 3 minutes of preoxygenation
To compare PaCO₂ between study groups after 3 minutes of preoxygenation (Unit of Measure: mmHg)
Time frame: At the end of 3 minutes of preoxygenation
Change in systolic blood pressure
Systolic arterial pressure will be recorded and compared between groups at the 5th minute after intubation
Time frame: At the 5th minute after intubation
Change in diastolic blood pressure
Diastolic arterial pressure will be recorded and compared between groups. (Unit of Measure: mmHg)
Time frame: At the 5th minute after intubation
Change in mean arterial pressure (MAP)
MAP will be recorded at the 5th minute after intubation (Unit of Measure: mmHg)
Time frame: At the 5th minute after intubation
Change in heart rate
Heart rate will be monitored and compared between groups at the 5th minute after intubation. \[Unit of Measure: beats per minute (bpm)\]
Time frame: At the 5th minute after intubation
Change in peripheral oxygen saturation (SpO₂)
SpO₂ will be monitored continuously and analyzed at the 5th minute after intubation. (Unit of Measure: percentage (%))
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PREVENTION
Masking
TRIPLE
Enrollment
128
Time frame: At the 5th minute after intubation