The aim of this study is an explorative prospective observation of retinal ganglion cell degeneration and/or inner retina degeneration in Retinitis pigmentosa patients. The rate and patterns of progression will be correlated to the outer retina layers as well as clinical and genetic data of patients. Secondary goal is to determine potential parameters for optogenetic treatment eligibility.
Study Type
OBSERVATIONAL
Enrollment
130
OCT, OCTA, RNFL-OCT, fundus autofluorescence, fundus imaging, flaremeter, fundus and slit lamp examination
EKFZ Else Kroener Fresenius Center for Optogenetic Therapies, University Medical Center Goettingen
Göttingen, Germany
Thickness of ganglion cell inner plexiforme layer (GCIPL) in OCT imaging
Measuring the thickness of the ganglion cell inner plexiforme layer (GCIPL) in macula optical coherence tomography (OCT) imaging of the retina.
Time frame: 6 months intervals, overall time span 5 years
Thickness of RNFL thickness in OCT imaging
Measuring the thickness of the retinal nerve fiber layer (RNFL) in macular and optic nerve optical coherence tomography (OCT) imaging of the retina.
Time frame: 6 months intervals, overall time span 5 years
PD, VD, ICA of the SRP and DRP with OCTA imaging
Perfusion density (PD), vessel density (VD), intercapillary area size (ICA) of superficial retinal plexus (SRP) and deep retinal plexus (DRP) in OCTA imaging (optical coherence tomography angiography)
Time frame: 6 months intervals, overall time span 5 years
Thickness and morphology of inner and outer retinal layers measured with OCT, fundus photography, FAF
Thickness and morphology of inner and outer retinal layers measured with optical coherence tomography (OCT), fundus photography, fundus autofluorescence (FAF)
Time frame: 6-12 months intervals, overall time span 5 years
Changes in functional parameters such as BCVA
Changes in functional parameters such as best corrected visual acuity
Time frame: 6 months intervals, overall time span 5 years
Correlations of outcome 1-5 with clinical data of patients
Find correlations of imaging outcomes with the clinical data of patients, such as sex, age, age of onset of disease
Time frame: 6 months intervals, overall time span 5 years
Correlations of outcome 1-5 with genetic data of patients
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Find correlations of imaging outcomes with the Retinitis pigmentosa mutation and inheritance pattern of patients
Time frame: 6 months intervals, overall time span 5 years
Correlation of outcome 1-5 with inflammatory markers
Correlation of imaging outcomes and disease progression with inflammatory markers collected with serum blood samples and flaremeter as well as slit lamp and fundus examination findings
Time frame: 6 months intervals, overall time span 5 years
Correlation of inner and outer retina parameters over time
Correlation of changes in inner retina and outer retina of collected imaging data over time.
Time frame: 6 months intervals, overall time span 5 years