Biomimetic Hydroxyapatite Toothpaste and Mouthwash for Reducing Dental Sensitivity

University of Pavia100 enrolled

Overview

This randomized controlled clinical trial evaluates the effectiveness of a biomimetic hydroxyapatite-based toothpaste and mouthwash in reducing dental sensitivity in patients with gingival recession. A total of 100 participants will be randomly assigned to two groups. The control group will receive Biorepair Total Protection toothpaste, and the trial group will receive Biorepair high-density mouthwash. Both products will be applied for 30 seconds. Dental sensitivity will be assessed before and after treatment using the Shiff Air Index and the Visual Analogue Scale (VAS).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Tooth Sensitivity Gingival Recession Generalized Moderate Gingival Recession Localized Moderate

Interventions

Biorepair Total Protection ToothpasteDEVICE

Application of Biorepair Total Protection toothpaste for 30 seconds, performed once in a clinical setting. The aim is to reduce dental sensitivity in patients with gingival recession.

Biorepair High-Density MouthwashDEVICE

Application of Biorepair High-Density mouthwash for 30 seconds, performed once in a clinical setting. The aim is to reduce dental sensitivity in patients with gingival recession.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male and female subjects aged between 18 and 70; * Subjects with gingival recession and tooth sensitivity; * Subjects who have agreed to give their free written informed consent to participate in the study. Exclusion Criteria: * Male and female subjects who are not adults; * Subjects without gingival recessions; * Subjects without dental sensitivity; * Subjects with poor participation or insufficient motivation to participate in this study.

Outcomes

Primary Outcomes

Change in Dental Sensitivity Measured by the Schiff Air Index

Variation in dental sensitivity scores assessed using the Schiff Air Index at baseline (T0) and after a 30-second application of either toothpaste or mouthwash (T1). The Schiff scale ranges from 0 (no response) to 3 (painful response to air stimulus), with higher scores indicating greater sensitivity.

Time frame: T0 (baseline) and T1 (immediately post-treatment, same visit)

Secondary Outcomes

Change in Pain Perception Measured by the Visual Analogue Scale (VAS)

Variation in perceived pain intensity related to dental sensitivity, reported by the patient using the Visual Analogue Scale (VAS) at two timepoints: T0 (baseline) and T1 (immediately after 30-second treatment with either toothpaste or mouthwash). The VAS is a 10 cm horizontal line ranging from 0 (no pain) to 10 (worst imaginable pain).