Evaluation of Post-Operative Pain Following the Use of Nano-Calcium Hydroxide

Cukurova University90 enrolled

Overview

The goal of this clinical trial is to evaluate the effect of different intracanal medicaments-conventional calcium hydroxide (CH) and nano-sized calcium hydroxide (NCH)-on the intensity of postoperative pain following root canal treatment in asymptomatic necrotic single-rooted teeth. The primary research question of this study is as follows: Does the use of nano-sized calcium hydroxide, compared to conventional calcium hydroxide, result in significantly reduced postoperative pain after root canal treatment? In both groups, standardized instrumentation will be performed using rotary NiTi files and 2.5% sodium hypochlorite irrigation. After cleaning and shaping, canals will be medicated with either CH or NCH, followed by temporary sealing.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Chronic Apical Periodontitis

Interventions

Following completion of canal shaping with rotary instrumentation and irrigation using 5 mL of 2.5% sodium hypochlorite (NaOCl), canals were flushed sequentially with 5 mL distilled water, 5 mL of 17% ethylenediaminetetraacetic acid (EDTA), another 5 mL of distilled water, 5 mL of 2.5% NaOCl, and finally 5 mL of distilled water. The cavity was sealed temporarily with a sterile cotton pellet and glass ionomer cement. Conventional calcium hydroxide was retained for 7 days before final obturation.

Nanocalcium Hydroxide (NCH)DRUG

Following completion of canal shaping with rotary instrumentation and irrigation using 5 mL of 2.5% sodium hypochlorite (NaOCl), canals were flushed sequentially with 5 mL distilled water, 5 mL of 17% ethylenediaminetetraacetic acid (EDTA), another 5 mL of distilled water, 5 mL of 2.5% NaOCl, and finally 5 mL of distilled water. The cavity was sealed temporarily with a sterile cotton pellet and glass ionomer cement. Nanocalcium hydroxide was retained for 7 days before final obturation.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18-65 years * Single-rooted permanent maxillary or mandibular teeth * Asymptomatic teeth with necrotic pulps confirmed by negative response to cold test * Presence of periapical radiolucency (PAI score 2-5) * No sensitivity to percussion or palpation * Patients who signed informed consent Exclusion Criteria: * Pregnancy or lactation * Systemic diseases requiring antibiotic prophylaxis (e.g., infective endocarditis, immunosuppression) * Use of antibiotics, corticosteroids, or analgesics within the past 7 days * History of chemotherapy or radiotherapy * Uncontrolled diabetes mellitus or hypertension * Chronic renal failure, hematologic disorders * Teeth with root resorption, previous endodontic treatment, or multirooted anatomy * Teeth with periodontal pockets \>4 mm or mobility * Inability to attend follow-up visits * Patients with extensive coronal destruction rendering definitive restoration unfeasible

Outcomes

Primary Outcomes

Visual Analogue Scale (VAS)

The visual analog scale for pain is a straight line with one end meaning no pain (0) and the other end meaning the worst pain (10) imaginable. A patient marks a point on the line that matches the amount of pain he or she feels. It may be used to help choose the right dose of pain medicine. Also called VAS.

Time frame: up to 72 hours