The study aimed to assess how a 6-month insulin sensitizer therapy impacts insulin resistance, glucose tolerance, and hormonal levels in women with PCOS. Researchers evaluated 156 PCOS patients, measuring their BMI, HOMA-IR (for insulin resistance), TyG index, TyG index-BMI, and total testosterone. Participants were divided into two groups, receiving either metformin or a myoinositol/d-chiro-inositol combination for six months, after which all parameters were re-evaluated to determine the percentage of change.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
156
metformin (MET) hydrochloride 500 mg three times daily as the standard insulin sensitizer.
myoinositol/d-chiro-inositol combination (MYO/DCI) in 40:1 ratiotwice daily
Benha university
Banhā, El Qalyoubia, Egypt
Success Rate of Treatment Regimens in Restoring Menstrual Regularity and/or Achieving Pregnancy
The proportion of patients who regained a regular menstrual pattern and/or achieved pregnancy during the study, reflecting the effectiveness of the administered treatment regimens.
Time frame: 6~7 Months
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