Prehabilitation includes care for patients preparing for surgery. This is a modern approach aimed at increasing the patient's functional capacity before surgery and improving postoperative results. Prehabilitation includes preoperative physical activity, nutritional intervention, psychological support, cessation of stimulants and optimization of laboratory test results. Many studies have shown a positive effect of prehabilitation on postoperative results, mainly reducing the number of postoperative complications and shortening the hospitalization time. The assumed time of prehabilitation is 2-6 weeks, but in the case of oncology patients, the procedure should not be delayed only for the sake of prehabilitation. Our study includes oncology patients with ovarian cancer who are referred for neoadjuvant chemotherapy before interval cytoreductive surgery. The assumption of the study is an intensive course of prehabilitation during neoadjuvant treatment, which should provide significantly better postoperative results.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
100
Patients referred to NACT (neoadjuvant chemotheraphy) for advanced ovarian cancer will undergo an intensive course of prehabilitation including physical exercise, a high-protein diet, protein and vitamin supplementation, optimization of laboratory test results, and psychological support will be provided.
Department of Gynecology, Obstetrics and Gynecological Oncology, University Clinical Center of the Medical University of Silesia
Katowice, Poland
Frequency of postoperative complications
Analysis of the incidence of complications, including assessment according to the Clavien-Dindo classification. Analysis of complications will include the incidence of intensive care units hospitalization, frequency of reoperation, dehiscence of intestinal anastomosis, wound dehiscence with eventeration, need for blood transfusion and readmission within 30 days
Time frame: from surgery for the next 30 days
Length of hospital stay
The analysis will include the length of hospitalization after surgery.
Time frame: from surgery to hospital discharge (assessed up to 14 days)
Time to start adjuvant chemotherapy
Comparison of time from hospital discharge to start of adjuvant chemotherapy
Time frame: from discharge from hospital for the next 2 months
Progression-free survival
Comparison of progression-free survival in both groups at 3 and 5 years of follow-up.
Time frame: From the time of the operation for the next 3 and 5 years
Overall survival
Comparison of overall survival in both groups at 3 and 5 years of follow-up
Time frame: From the time of the operation for the next 3 and 5 years
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