Assessment of Circuit Rebreathing During CPAP Therapy

Overview

The goal of this research is to better understand how different CPAP mask designs affect airflow and rebreathing of exhaled carbon dioxide (CO₂) during sleep in individuals with obstructive sleep apnea (OSA).

To understand the existence and severity of circuit rebreathing during treatment with continuous positive airway pressure (CPAP) using different sizes of the exhaust ports in individuals with obstructive sleep apnea (OSA). Flow-adjusted end-tidal oxygen (PetO2) and carbon dioxide (PetCO2) will be assessed to determine the magnitude of hypoxic load during both wakefulness and sleep. To systematically assess these conditions, the conditions were defined as follows: * 5A: 35 L/s exhaust flow with 5 cmH₂O PAP * 5B: 23 L/s exhaust flow with 5 cmH₂O PAP * 5C: 18 L/s exhaust flow with 5 cmH₂O PAP * 5D: 13 L/s exhaust flow with 5 cmH₂O PAP * 5E: 8 L/s exhaust flow with 5 cmH₂O PAP * 0P: 35 L/s exhaust flow with 0 cmH₂O PAP * 10A: 35 L/s exhaust flow with 10 cmH₂O PAP * 10B: 23 L/s exhaust flow with 10 cmH₂O PAP * 10C: 18 L/s exhaust flow with 10 cmH₂O PAP * 10D: 13 L/s exhaust flow with 10 cmH₂O PAP * 10E: 8 L/s exhaust flow with 10 cmH₂O PAP Primary endpoint is to evaluate the effect of exhaust flow on flow-adjusted average inspired oxygen fraction (FiO₂) during (1) wakefulness and (2) sleep between 5B vs. 5D.

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Central Contacts