Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude. Additionally, the differences between low and moderate altitude will also be examined.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
52
Standard ambiant air will be breathed during endurance training. ambiant air
SSOT and sham air (5l/min) will be applied with the oxygen concentrator EverFloTM via nasal cannula during training
Standard ambiant air will be breathed during endurance training. ambiant air
National center for cardiology and internal medicine
Bishkek, Kyrgyzstan, Kyrgyzstan
Eastern Switzerland University of Applied Sciences
Sankt Gallen, Canton of St. Gallen, Switzerland
1. Change in Rrs (Respiratory System Resistance) before and after rehabilitation cycle
Rrs will be measured using the forced oscillation technique (FOT) in cmH₂O·s/L. Values will be assessed before and after the pulmonary rehabilitation cycle at moderate altitude
Time frame: baseline to 3 weeks
Change in Xrs (Respiratory System Reactance) compared before and after the pulmonary rehabilitation.
Xrs will be measured using FOT in cmH₂O·s/L. Values will be compared before and after the pulmonary rehabilitation
Time frame: baseline to 3 weeks
Change in ∆Xrs (Difference in Reactance) before and after rehabilitation
∆Xrs will be calculated as the difference between inspiratory and expiratory Xrs values, measured in cmH₂O·s/L, before and after rehabilitation.
Time frame: baseline to 3 weeks
Change in Rrs, Xrs and ∆Xrs from low to moderate altitude
Time frame: From baseline at low altitude to transfer to moderate altitude at 3 days
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