Intraoperative Pathologic Evaluation of Central Lymph Nodes in Papillary Thyroid Carcinoma

Seoul National University Hospital509 enrolled

Overview

Efficacy of Intraoperative pathologic evaluation of central lymph nodes

This study aimed to evaluate the effectiveness of intraoperative pathological examination and determine the risk factors for central lymph node metastasis in patients with unilateral clinically node-negative (cN0) papillary thyroid carcinoma.

Study Type

OBSERVATIONAL

Enrollment

509

Conditions

Thyroid Cancer, Papillary

Interventions

central node dissectionPROCEDURE

dissection of level VI compartment by AAHNS (American association of head and neck surgeons) classification

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * patients with unilateral papillary thyroid cancer * no evidence of lymph node metastasis (clinically N0) * performed with Intraoperative pathologic evaluation Exclusion Criteria: * those with a history of neck surgery * those with lateral lymph node metastasis * those with suspected extrathyroidal extension * those in whom Intraoperative pathologic evaluation was not performed

Locations (1)

Seoul National University Hospital

Seoul, Jongno-gu, South Korea

Outcomes

Primary Outcomes

the accuracy of IOPE

To evaluate IOPE accuracy, the findings were compared with the final pathology results, utilizing key parameters such as sensitivity, specificity, false-negative rate (FNR), and false-positive rate for analysis.

Time frame: Perioperative

Secondary Outcomes

the incidence of complications in IOPE [safety of IOPE]

The safety was evaluated by examining the incidence of complications, including vocal cord palsy and hypoparathyroidism. vocal cord palsy : measured by laryngeal sono hypoparathyroidism : serum parathyroid hormone levels \< 15.0 pg/mL

Time frame: up to 6 months

the risk factors for central lymph node metastasis

To determine the risk factors for central lymph node metastasis, univariate and multivariate logistic regression analyses were performed to identify the correlations between clinicopathological characteristics and the final pathological presence of central lymph node metastasis. clinicopathological factors : sex, age (\<55, ≥55), sonographic features, size (\<1cm, ≥1cm) presence of central lymph node metastasis was confirmed by final pathology

Time frame: perioperative

Data from ClinicalTrials.gov

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