Mortality Outcome of Controlled Blood Pressure Participants

N/AActive Not RecruitingNCT07067632

DejthidaNathaphong100 enrolled

Overview

Despite advances in antihypertensive therapy, some patients with well-controlled blood pressure still experience fatal outcomes. This paradox raises critical questions about the efficacy of blood pressure-targeted interventions and whether BP control alone ensures survival. This systematic review and meta-analysis aims to evaluate all-cause mortality and cardiovascular death among hypertensive patients who achieved BP targets in RCTs or open-label trials. To determine whether achieving controlled blood pressure through intentional intervention (pharmacological or procedural) in RCTs or open-label studies reduces mortality (all-cause and cardiovascular) in hypertensive patients.

Sensitivity Analyses Excluding high-risk of bias studies Excluding short follow-up (\<1 year)

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Valid MeSH Conditions Hypertension (HTN)

Interventions

Antihypertensive treatmentDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults ≥18 years with diagnosed hypertension Blood pressure controlled at target values defined by the study (e.g., \<140/90 mmHg or \<130/80 mmHg) Any comorbidity allowed unless the study focuses on pregnancy or pediatric population Exclusion Criteria: * Observational or retrospective studies Pediatric or pregnant participants Case reports, editorials, or conference abstracts without full data Studies not reporting mortality outcomes separately for controlled BP

Outcomes

Primary Outcomes

All-cause mortality

All cause mortality by controlable hypertension treatment

Time frame: 100 year