Analysis of Psychoneuroimmunological Parameters of Health in Specific Population Groups in Slovakia

N/AActive Not RecruitingNCT07070180

Comenius University700 enrolled

Overview

This study aims to investigate the links between psychological and biological immunity from the perspective of psychology, epidemiology, and immunology in a general population study sample as well as in a specific group of people in treatment for alcohol addiction.

The study will explore the associations between the level of psychological immunity and the current psychological state of the participants, possible links between the level of psychological immunity in adulthood and adverse childhood experiences, and finally, the association between the psychological immunity and biological immunity expressed by the self- assessed perceived immune status and on a molecular level by quantity of cytokines and in a specific subgroup also by natural killer cells. All this will be studied in a sample of general population as well as in a specific group of people in treatment for alcohol addiction that was chosen based on the known adverse immune-related health effects of excessive alcohol consumption.

Study Type

OBSERVATIONAL

Enrollment

700

Conditions

Immunity Cytokine Levels Psychological Adaptation Resilience Positive Thinking Sense of Control

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for 'General Slovak Population Sample': * Age between 18 - 50 years * Residency in the respective region for at least five years * Consent to participate in the study Exclusion Criteria for 'General Slovak Population Sample': * Individuals younger than 18 or older than 50 years * Ongoing acute infectious disease on the day of testing * Eligible individuals who do not provide informed consent Inclusion Criteria for the sample 'Individuals receiving inpatient treatment for alcohol addiction at the treatment facility': * Age between 18 - 50 years * Admission to treatment for alcohol addiction * Consent to participate in the study, Treatment completion Exclusion Criteria for the sample 'Individuals receiving inpatient treatment for alcohol addiction at the treatment facility': * Individuals younger than 18 or older than 50 years * Eligible individuals who do not provide informed consent * Drop-out from alcohol addiction treatment

Locations (3)

Comenius University Bratislava, Faculty of Arts

Bratislava, Slovakia

Comenius University, Faculty of Medicine in Bratislava

Bratislava, Slovakia

Slovak Academy of Sciences, Institute of Neuroimmunology

Bratislava, Slovakia

Outcomes

Primary Outcomes

The primary outcome measure is the correlation between psychological immunity, current health status and cytokine levels as indicators of biological immune function.

The psychological instrument will consist of the Psychological immune competence inventory (PICI) to assess the psychological immunity. Current health status will be assessed by the epidemiological instrument that will evaluate self-assessed immune status, overall, mental, and physical health, current long-term conditions, social, and economic status. Units of measure for the questionnaires is a score. Cytokine secretion by immune cells will be tested using Bio-Plex ProTM Human Cytokine 17- plex assay according to the instructions of the manufacturer. For the analysis the blood plasma will be used. In each sample the following panel of cytokines will be analysed: G- CSF, GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, IL-17A, MCP-1 (MCAF), MIP-1β, TNF-α. Cytokine units of measure are picograms per milliliter.

Time frame: At the time of study enrollment for Group 1, at the time of admission in treatment and after completion of 3 months of treatment for Group 2