Radiotherapy is an important treatment for many malignant tumors. However, radioresistance remains a major cause of treatment failure, often leading to tumor recurrence or progression. As a key factor affecting prognosis, radioresistance currently lacks reliable methods for identifying high-risk individuals before treatment. Liquid biopsy, as a non-invasive and dynamic monitoring tool, offers unique advantages for real-time assessment. Previous studies from our group have shown that peripheral blood levels of CHI3L1 are significantly elevated in patients with radioresistant tumors and may serve as a predictive biomarker for radiotherapy sensitivity. This study aims to conduct a multicenter, bidirectional cohort study to systematically evaluate the predictive value of peripheral blood CHI3L1 as a pan-cancer biomarker for tumor response to radiotherapy.
Study Type
OBSERVATIONAL
Enrollment
338
Nanfang hospital, Southern medical university, Guangzhou, Guangdong 510515
Guangzhou, Guangzhou, China
Huizhou Central People's Hospital, Huizhou
Huizhou, China
Meizhou People's Hospital, Meizhou Academy of Medical Sciences Meizhou, Meizhou,
Meizhou, China
Objective Response Rate(ORR)
Objective Response Rate (ORR) after Radiotherapy in Tumor Patients
Time frame: Through study completion, up to 3 years
Local Control Rate
Local Control Rate after Radiotherapy in Tumor Patients
Time frame: Through study completion, up to 3 years
Local Relapse Free Survival
Locoregional Recurrence-Free Survival after Radiotherapy in Tumor Patients
Time frame: Through study completion, up to 3 years
Progression Free Survival
Progression-Free Survival after Radiotherapy in Tumor Patients
Time frame: Through study completion, up to 3 years
Overall Survival
Overall Survival after Radiotherapy in Tumor Patients
Time frame: Through study completion, up to 3 years
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