The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, as well as preliminary efficacy of mRNA encoding CD19/CD3 T cell engager (ABO2203) in adult patients with relapsed or refractory CD19-positive B-NHL, This study included dose escalation and dose expansion parts.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
56
SC or IV
Ruijin Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGA study of mRNA encoding CD19/CD3 T cell engager (ABO2203) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL)
The incidence and severity of adverse events evaluated by Common Terminology Criteria for Adverse Events (CTCAE)
Time frame: From the first dose to 30 days after the last dose of ABO2203 treatment
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