The aim of the study is to compare the efficacy and safety of XW003 injection versus semaglutide injection in Chinese adults with obesity
In this Phase II study, eligible participants will be randomized into one of the two cohorts in a 1:1 ratio to receive once-weekly subcutaneous XW003 injection or semaglutide injection, including a dose-escalation period, a core treatment period and a treatment extension period, for up to 60 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
163
Subcutaneous injection
Subcutaneous injection
Peking University People's Hospital
Beijing, Beijing Municipality, China
Percentage change in body weight relative to baseline
Time frame: week 48
Proportions of participants with weight loss ≥5% from baseline
Time frame: week 48
Proportions of participants with weight loss ≥10% from baseline
Time frame: week 48
Proportions of participants with weight loss ≥15% from baseline
Time frame: week 48
The change in waist circumference relative to the baseline
Time frame: week 48
Changes in body mass index (BMI) relative to baseline
Time frame: week 48
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