This study aims to rigorously assess the effectiveness of LPCGF in the management of internal disc displacement in patients with TMD through a randomized clinical trial. By comparing LPCGF therapy with conventional arthrocentesis, this research looks to provide robust evidence on the efficacy, safety, and potential role of (LPCGF) as an alternative therapeutic choice for IDD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
32
16 patients with anterior disc displacement with or without reduction randomly allocated to be treated with injection of liquid phase concentrated growth factor
16 patients with anterior disc displacement with or without reduction randomly allocated to be treated with conventional arthrocentesis
Faculty of Dentistry- Horus University in Egypt
Damietta, New Damietta, Egypt
Assess and comparing the pain of both groups
measured using the Visual Analog Scale (VAS), ranging from 0 (no pain) to 10 (worst pain)
Time frame: Assessed at baseline (before treatment),1week, 1 month, 3 months, and 6 months after the intervention.
Assess and comparing the mouth opening of both groups
measured in millimeters (Maximum inter-incisal opening measured by the distance in millimeters between the incisal edges of the upper and lower central incisors in vertical direction at maximum pain free mouth opening) by using caliper. and comparing the results of both groups
Time frame: Assessed at baseline (before treatment),1week, 1 month, 3 months, and 6 months after the intervention.
Joint sounds
(clicking and crepitus) evaluated by clinical examination; presence of joint noise at opening and closing was evaluated by light bilateral digital palpation during jaw movement.
Time frame: Assessed at baseline (before treatment),1week, 1 month, 3 months, and 6 months after the intervention.
Mandibular deviation during mouth opening.
By clinical examination , observe mandibular deviation toward right or left side or deflection during opening and closing the mouth
Time frame: Assessed at baseline (before treatment),1week, 1 month, 3 months, and 6 months after the intervention.
Lateral and protrusive movements
(Range of lateral and protrusive movements measured by the distance in millimeters between the upper and lower midlines in horizontal direction on lateral and protrusive movements by using caliper).
Time frame: Assessed at baseline (before treatment),1week, 1 month, 3 months, and 6 months after the intervention
tenderness on palpation
Presence or absence of joint tenderness on palpation: recorded as tender or not tender.
Time frame: Assessed at baseline (before treatment),1week, 1 month, 3 months, and 6 months after the intervention.
TMD symptoms
TMD symptoms were evaluated using Modified Helkimo Index
Time frame: Assessed at baseline (before treatment),1week, 1 month, 3 months, and 6 months after the intervention.
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