Oral Caffeine and Spinal-Induced Hypotension

Cairo University90 enrolled

Overview

Hypotension after spinal anesthesia is critical. Thus several interventions have been proposed to mitigate such effect.

Hypotension is a critical issue related to spinal anesthesia during cesarean delivery. Researchers of this study aimed to evaluate the impact of preoperative oral caffeine on the incidence of spinal hypotension during cesarean delivery.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Spinal Hypotension Caffeine

Interventions

Caffeine (200 mg)DRUG

Oral caffeine will be given as 200 mg before spinal anesthesia

PlaceboDRUG

Patient at this arm will receive placebo

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * full term pregnant * undergoing elective cesarean delivery Exclusion Criteria: * patient refusal * baseline systolic pressure \< 100 mmHg * contraindication to spinal anesthesia * allergy to caffeine

Locations (1)

Cairo University

Cairo, Cairo Governorate, Egypt

Outcomes

Primary Outcomes

Incidence of spinal hypotension

Decrease systolic blood pressure \< 20% of baseline value

Time frame: After spinal anesthesia till delivery

Secondary Outcomes

Time to first hypotensive episode

time to incidence of hypotension

Time frame: after induction of spinal anesthesia

Incidence of severe hypotension

reduced systolic pressure \< 60% of baseline value

Time frame: After onset of spinal anesthesia

APGAR score

APGAR score calculation at 5 minutes

Time frame: at 5 minutes after delivery

Umbilical artery pH

Umbilical artery blood gases

Time frame: At 5 minutes after delivery

Data from ClinicalTrials.gov

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