The goal of this clinical trial is to learn whether 89Zr-Girentuximab PET scans can inform management of renal cell carcinoma. The main questions it aims to answer are: * Does the 89Zr-Girentuximab PET detect ccRCC that is left behind or has come back after treatment? * What differences can be seen on the 89Zr-Girentuximab PET before and after standard of care treatment? Participants in arm 1 will be given the study drug followed by a PET scan 3-7 days after injection. Participants in arm 2 will receive the same, but will proceed with their standard of care cryoablation after the initial PET scan. Within 3 days of the cryoablation treatment, participants will receive a repeat PET scan.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
10
89Zr-Girentuximab PET
Massachusetts General Hospital
Boston, Massachusetts, United States
SUVmean of the ablated zone and adjacent or contralateral uninvolved kidney
Qualitative and quantitative assessment of 89Zr-girentuximab probe uptake of the ablative zone in the kidney will be performed. Guided by the findings of standard CT or MRI, a region of interest (ROI) will be drawn over the ablation zone and adjacent uninvolved kidney. SUVmean of the ROIs will be measured for the recurrent/residual tumor and the adjacent or contralateral normal kidney. Descriptive statistics including the mean SUVmean and standard deviation will be reported for each ROI. Tumor to kidney uptake ratio will also be calculated. It is expected that the recurrent/residual tumor will show uptake above the uninvolved kidney.
Time frame: From enrollment to 0-3 days after SOC cryoablation
SUVmax of the ablated zone and adjacent or contralateral uninvolved kidney
Qualitative and quantitative assessment of 89Zr-girentuximab probe uptake of the ablative zone in the kidney will be performed. Guided by the findings of standard CT or MRI, a region of interest (ROI) will be drawn over the ablation zone and adjacent uninvolved kidney. SUVmax of the ROIs will be measured for the recurrent/residual tumor and the adjacent or contralateral normal kidney. Descriptive statistics including the SUVmax and standard deviation will be reported for each ROI. Tumor to kidney uptake ratio will also be calculated. It is expected that the recurrent/residual tumor will show uptake above the uninvolved kidney.
Time frame: From enrollment to 0-3 days after SOC cryoablation
Comparison of SUVmean on pre- and post-ablation scans
Guided by the standard CT or MRI, an ROI will be defined over the primary kidney tumor and adjacent uninvolved kidney on the scans before and after cryoablation. SUVmean as well as tumor to kidney ratio will be calculated on the pre- and post-ablation scans to evaluate whether the uptake decreases immediately after ablation.
Time frame: Baseline through 0-3 days days after SOC cryoablation
Comparison of SUVmax on pre- and post-ablation scans
Guided by the standard CT or MRI, an ROI will be defined over the primary kidney tumor and adjacent uninvolved kidney on the scans before and after cryoablation. SUVmax as well as tumor to kidney ratio will be calculated on the pre- and post-ablation scans to evaluate whether the uptake decreases immediately after ablation.
Time frame: Baseline through 0-3 days after SOC cryoablation
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